Synthesis and Investigation of the Targeted Drug Delivery Systems Based on Bimetallic Nanoparticles Au–FeOх

New targeted drug delivery systems based on bimetallic AuFe nanoparticles and their conjugates with methotrexate were obtained in different media (acetone and toluene) by the metal-vapor synthesis (MVS). The introduction of methotrexate resulted in a reduction of Fe in both media. In the Au 4f spectra, both gold reduction for the toluene medium and oxidation for the acetone medium were observed. An increase in the size of metal nanoparticles in the presence of methotrexate was observed exclusively in acetone. MTT assay revealed high inhibitory potential of the bimetal conjugates in low concentrations.