Intracellular IL1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma
Glycolysis upregulates intracellular IL1α that reprograms peritumoral monocytes by translocating into the nucleus to induce prometastatic IL8 production or binding to mitochondria to stimulate prosurvival CA12 expression.
Authors
- Kun Huang (ORCID: https://orcid.org/0009-0000-9125-1320)
- Jiaying Gong (ORCID: https://orcid.org/0009-0009-6612-7809)
- Ai-Qi Huang (ORCID: https://orcid.org/0000-0002-4278-9463)
- Dong‐Ming Kuang (ORCID: https://orcid.org/0000-0003-3570-9717)
- Da Jiang (ORCID: https://orcid.org/0000-0002-0483-2192)
- Bai-Xi Zhu (ORCID: https://orcid.org/0009-0001-8256-9772)
- Xing-Chen Liu (ORCID: https://orcid.org/0000-0002-8462-2936)
- Yan Wu (ORCID: https://orcid.org/0000-0002-9022-9794)
- Yong-Hao Ruan (ORCID: https://orcid.org/0000-0003-3467-6618)
- Wan-Ru Ning (ORCID: https://orcid.org/0000-0002-4857-4981)
- Limin Zheng (ORCID: https://orcid.org/0000-0002-8281-1450)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3355
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00