Effect of miR-6767-5p on breast cancer cell phenotype and its regulatory mechanism
(1) miR-6767-5p is highly expressed in BC cells, stimulating their proliferation, migration, and invasion both in vivo and in vitro. (2) miR-6767-5p activates the NF-κB signaling pathway and the EMT by specifically inhibiting CRIP2. (3) The expression of miR-6767-5p is regulated by MAP2K4 through the upregulation of c-jun. (4) The expression of miR-6767-5p is positively correlated with the stage of breast cancer and a poor prognosis for patients.
Authors
- Shu Liu (ORCID: https://orcid.org/0009-0000-2914-1091)
- Zhen Tan (ORCID: https://orcid.org/0000-0002-3651-1916)
- Fulin Zhou (ORCID: https://orcid.org/0000-0002-5489-3356)
- Yu Ren
Institutions
- Guiyang Medical University (CN)
- Guizhou Cancer Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Liupanshui Normal University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1038/s41598-025-16537-w
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China