The effect of cognition on the association between cerebral small vessel disease burden and motor function: a cross-sectional study
The CSVD burden influences both SPPB score and knee ROM in patients with mild to moderate cognitive and motor impairments, either directly or indirectly through cognitive decline. Cognitive function, as measured by the MoCA score, plays a significant mediating role in the association between CSVD burden and both SPPB score and knee ROM.
Authors
- Ying Gao (ORCID: https://orcid.org/0000-0002-4776-3641)
- Xiaoling Liao (ORCID: https://orcid.org/0000-0003-4620-9224)
- Hui Qu (ORCID: https://orcid.org/0000-0002-7610-6413)
- Yuesong Pan (ORCID: https://orcid.org/0000-0003-3082-6789)
- Yilong Wang (ORCID: https://orcid.org/0000-0003-2725-2788)
- Weiqi Chen
- Tingting Wang (ORCID: https://orcid.org/0000-0002-8452-2927)
- Ling Guan (ORCID: https://orcid.org/0000-0003-3381-8370)
- Shuo Yang (ORCID: https://orcid.org/0000-0003-4225-6787)
- Hua Pan (ORCID: https://orcid.org/0009-0001-1526-7205)
- Hongyi Yan (ORCID: https://orcid.org/0000-0003-4185-0506)
Institutions
- University of British Columbia (CA)
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Chinese Institute for Brain Research (CN)
- Beijing Fengtai Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s40001-025-03063-8
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing Municipal Science and Technology Commission
- National Science and Technology Major Project