Targeted neural stem cell-derived extracellular vesicles loaded with Sinomenine alleviate diabetic peripheral neuropathy via WNT5a/TRPV1 pathway modulation
ZH-1c-EVs@SIN represents a promising therapeutic strategy for DPN, offering targeted immunomodulation and enhanced neural repair via regulation of the WNT5a/TRPV1 signaling axis. This nano-delivery platform introduces a novel and precise approach to intervening in diabetic neuropathy and may be applicable to other neuroinflammatory conditions.
Authors
- Y.J. Chen (ORCID: https://orcid.org/0000-0002-1132-3310)
- Ji Chen (ORCID: https://orcid.org/0000-0003-0326-8304)
- Lin Zhu (ORCID: https://orcid.org/0000-0002-6503-3386)
- Xinxin Liu (ORCID: https://orcid.org/0000-0003-2739-2334)
- Wen Chen (ORCID: https://orcid.org/0000-0003-0709-7653)
- Fengrui Yang (ORCID: https://orcid.org/0009-0006-7132-4792)
Institutions
- Huaihua University (CN)
- Hunan International Economics University (CN)
- Hunan University (CN)
- Shantou University (CN)
- Yue Bei People's Hospital (CN)
- First Affiliated Hospital of University of South China (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12951-025-03678-3
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China