Gastric juice MicroRNAs as biomarkers for functional dyspepsia: an observational case-control study
FD patients might have altered gastric juice miRNA profiles, notably an upregulation of miR-21, and distinctive differences between PDS and EPS subtypes. The PDS subtype is characterized by a high-miR-21 and miR-155 and low-miR-203 signature, whereas the opposite pattern is observed in EPS. These miRNA alterations align with the symptomatology of FD subtypes and may reflect underlying pathophysiological differences. Gastric juice miRNAs could serve as minimally invasive biomarkers for FD, aiding in differentiating functional subgroups and potentially guiding targeted therapies. Further studies are warranted to confirm this findings and establish their diagnostic utility and role in FD pathogenesis.
Authors
- Oana Zănoagă (ORCID: https://orcid.org/0000-0001-9574-0914)
- Teodora Surdea‐Blaga (ORCID: https://orcid.org/0000-0001-6020-4724)
- Radu A. Fărcaș (ORCID: https://orcid.org/0000-0002-5672-7343)
- Flaviu Rusu (ORCID: https://orcid.org/0000-0003-3979-4971)
- Alexandra Chira (ORCID: https://orcid.org/0000-0001-9092-065X)
- Vlad-Ionuț Nechita (ORCID: https://orcid.org/0000-0002-3097-707X)
- Ștefan Strilciuc (ORCID: https://orcid.org/0000-0001-6112-0223)
- Liviuţa Budişan (ORCID: https://orcid.org/0000-0001-5725-662X)
- Cristina Maria Sabo (ORCID: https://orcid.org/0009-0008-0830-9009)
- Stefan‐Lucian Popa (ORCID: https://orcid.org/0000-0002-5508-2598)
- Dan L. Dumitrascu
Institutions
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Academia Oamenilor de Știință din România (RO)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fmed.2025.1636825
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00