Decoding the hypoxic tumor microenvironment in colorectal cancer for prognostic modeling and therapeutic target discovery
We present a robust hypoxia-related gene signature that accurately predicts CRC patient prognosis and nominate GIPC2 as a potential biomarker and therapeutic target, offering new insights into hypoxia-driven CRC biology and personalized treatment strategies.
Authors
- Meng He (ORCID: https://orcid.org/0000-0003-3283-3325)
- Jia Hao (ORCID: https://orcid.org/0000-0001-9836-9014)
- Haibo Jiang (ORCID: https://orcid.org/0000-0001-6635-8353)
- Xiaocui Duan (ORCID: https://orcid.org/0009-0006-8076-1548)
- Yu-Hang Liu
- Huayang Pang
- Zhe Han (ORCID: https://orcid.org/0000-0002-9810-817X)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0001-8365-9051)
- Zhou Yan (ORCID: https://orcid.org/0000-0002-5623-0193)
- Meilin Wang (ORCID: https://orcid.org/0000-0002-6345-1699)
- Hongpan Xu (ORCID: https://orcid.org/0000-0002-8957-8225)
- Fan Feng (ORCID: https://orcid.org/0000-0003-1978-2914)
Institutions
- Hebei Medical University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1651749
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00