Two Decades of Outcomes and Quality of Life Following Pencil Beam Scanning Proton Therapy in Children and Adolescents with Rhabdomyosarcoma
Our two decades of experience with PBS PT provide data that reflect good local control rates and minimal late non-ocular grade 3 toxicity. We also show that quality of life returned to normal scores in nearly all domains within 2 years. Children and adolescents with RMS seem to benefit from PBS PT in terms of toxicity and quality of life, but further prospective, multi-institutional comparative trials are needed.
Authors
- Gabriele Calaminus (ORCID: https://orcid.org/0000-0002-7893-7982)
- Tobias M. Dantonello (ORCID: https://orcid.org/0000-0003-0050-5327)
- Reinhardt Krcek (ORCID: https://orcid.org/0009-0009-9686-5802)
- Dominic Leiser (ORCID: https://orcid.org/0000-0001-7535-1751)
- Damien C. Weber (ORCID: https://orcid.org/0000-0003-1166-8236)
- Jochen Karl Rössler (ORCID: https://orcid.org/0000-0003-4022-4917)
- Léonie Grawehr (ORCID: https://orcid.org/0009-0005-7268-0492)
Institutions
- University of Bern (CH)
- University of Bonn (DE)
- University Hospital Bonn (DE)
- University Hospital of Bern (CH)
- Paul Scherrer Institute (CH)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3390/cancers17172771
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00