Intranasal Wharton's Jelly‐Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic‐Ischemic Brain Injury in Mice
This study provides new translational evidence that intranasal WJ-MSCs, either alone or in combination with hypothermia, mitigate the consequences of neonatal HIBI by resolving inflammation and boosting neurorepair through their secretome. ANN NEUROL 2025;98:1380-1394.
Authors
- Sabine van Rijt (ORCID: https://orcid.org/0000-0003-4102-4626)
- Diego Ardigò
- Manon J.N.L. Benders (ORCID: https://orcid.org/0000-0001-5491-9168)
- Josine E. G. Vaes
- Caroline G. M. de Theije (ORCID: https://orcid.org/0000-0003-1265-7897)
- Giorgia Volpi
- Cora H. Nijboer (ORCID: https://orcid.org/0000-0003-1223-1861)
- Stephanie Palma (ORCID: https://orcid.org/0009-0001-5943-8539)
- Frank van Bel (ORCID: https://orcid.org/0000-0003-2769-4180)
- Katiuscia Dallaglio
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Chiesi Foundation (IT)
- Wilhelmina Children's Hospital (NL)
- Chiesi (France) (FR)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1002/ana.78000
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chiesi Farmaceutici
- Horizon 2020 Framework Programme