The methylation site cg06972019 regulates the succinylation-related gene ENO1 to inhibit the occurrence of erectile dysfunction
This study revealed the potential causal relationship of the ENO1 gene in the development of ED through Mendelian Randomization and SMR analysis, further validating the association between gene expression and ED. The overexpression of the ENO1 gene may be regulated by the methylation site cg06972019. These findings provide new insights into the molecular mechanisms of ED and may offer new biomarkers for the early diagnosis and targeted treatment of ED.
Authors
- Siyuan Ye (ORCID: https://orcid.org/0000-0003-0595-4682)
- Jian Wang (ORCID: https://orcid.org/0000-0002-7286-5041)
- Yang Lü (ORCID: https://orcid.org/0000-0002-3784-7577)
- Mengru Sun (ORCID: https://orcid.org/0000-0003-3603-6307)
- Zheng Fu Piao
- Fengmeng Teng
- Maosen Zhang (ORCID: https://orcid.org/0000-0002-7859-502X)
- Mingmin Xu (ORCID: https://orcid.org/0009-0000-7274-5990)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangning District of Nanjing Chinese Medicine Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s41065-025-00543-z
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00