Single-Cell Transcriptomics Reveals Effects of Long-Term Contact Lens Wearing on the Human Corneal Epithelium
Long-term wear of CLs may induce various manifestations in corneal epithelial cells, including keratinization, inflammatory response, aerobic metabolic impairment, cellular senescence, neovascularization, and corneal sensory abnormalities. These changes could compromise ocular surface barrier function and increase the risk of infectious keratitis.
Authors
- Luqin Wan
- Ning Wang (ORCID: https://orcid.org/0000-0003-4647-5880)
- Shengqian Dou (ORCID: https://orcid.org/0000-0002-8087-0115)
- Qun Wang (ORCID: https://orcid.org/0000-0002-0136-7467)
- Min Chen (ORCID: https://orcid.org/0000-0002-6906-872X)
- Ting Liu (ORCID: https://orcid.org/0000-0002-4132-5448)
- Dewei Li (ORCID: https://orcid.org/0000-0002-4897-7561)
- Yi Song (ORCID: https://orcid.org/0000-0002-5015-920X)
- Xiaowen Zhang
- Di Sun (ORCID: https://orcid.org/0009-0003-2040-1709)
- Le Tian
Institutions
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1167/iovs.66.11.59
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China