The gut as a mediator of environmental harm: unveiling microbial pathways in climate-related disease. Author’s reply

The gut as a mediator of environmental harm 1 a gut-kidney axis linking the gut microbiome and renal function / diseases via a bidirectional relationship. 3,4In their comprehensive review, Hou et al 5 summarized the multiple links between microbiota dysbiosis and several diseases affecting not only the cardiovascular and renal systems but also the brain, the lung, and the gastrointestinal tract, as well as diabetes and cancer (FIguRE 1).Hence, I agree that one should "incorporate gut microbial ecology into the broader climate-health paradigm" as concluded by Marlicz et al. 1 That said, I am also glad to read that the World Gastroenterology Organization and the United Author's reply I am grateful to Marlicz et al 1 for their insightful comments on the role of the gut as a mediator of cardiovascular and renal complications through the impact of pollutants on microbiota.It is true that I did not cover the role of the gut microbiome in my review, and I apologize for having missed this important issue.As pointed out, in last decades, increasing evidence has been gathered indicating that the gut microbiome is associated with blood pressure regulation and, more recently, with the development of some forms of experimental hypertension. 2However, data from human studies are still scarce.There is also evidence of