β-Sitosterol preconditioning enhances the resistance of BMSCs and chondrocyte to oxidative stress and promotes cartilage repair in osteoarthritis
These findings suggest that β-sitosterol possesses significant antioxidative and chondroprotective properties, which enhance the therapeutic efficacy of BMSCs in addressing OA-related cartilage damage.
Authors
- Zhenlei Zhou (ORCID: https://orcid.org/0000-0002-1398-6345)
- Hongfan Ge
- Qi Chang (ORCID: https://orcid.org/0000-0001-7985-580X)
- Yanyan Zhang (ORCID: https://orcid.org/0000-0002-2827-8042)
- Chengyin Liu (ORCID: https://orcid.org/0000-0002-4816-152X)
- Xiaoman Wang (ORCID: https://orcid.org/0000-0002-6009-2619)
Institutions
- Nanjing Agricultural University (CN)
- People's Liberation Army No. 150 Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s13287-025-04613-x
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- National Natural Science Foundation of China
- Nanjing Agricultural University
- Chinese People’s Liberation Army