Structural brain differences in school-aged children who are HIV-exposed uninfected
These findings suggest that in utero HIV and ART exposure have broad neuroanatomic developmental impacts, particularly in boys, with significant differences in brain regions critical for motor function, expressive language, memory, and emotion. These structural differences align with previously reported motor and language deficits and highlight the importance of early intervention and tailored support strategies for CHEU.
Authors
- Elka Miller (ORCID: https://orcid.org/0000-0003-1075-5952)
- Mary Lou Smith (ORCID: https://orcid.org/0000-0002-1937-1026)
- Lena Serghides (ORCID: https://orcid.org/0000-0002-2817-6134)
- J. Christopher Young (ORCID: https://orcid.org/0000-0001-7219-7824)
- Cassandra Kapoor (ORCID: https://orcid.org/0000-0002-3301-6346)
- Jennifer Bowes (ORCID: https://orcid.org/0000-0002-1000-0245)
- Bilal Syed (ORCID: https://orcid.org/0000-0002-7020-5488)
- Jason P. Lerch (ORCID: https://orcid.org/0000-0002-4871-8578)
- Jason Brophy
- Ari Bitnun (ORCID: https://orcid.org/0000-0001-5289-5430)
- Mark Head (ORCID: https://orcid.org/0000-0003-2034-8613)
- John G. Sled (ORCID: https://orcid.org/0000-0002-4461-283X)
- Eve A. Forster
- Margot J. Taylor
Institutions
- University Health Network (CA)
- University of Ottawa (CA)
- University of Toronto (CA)
- Children's Hospital of Eastern Ontario (CA)
- Hospital for Sick Children (CA)
- Women's College Hospital (CA)
- Toronto General Hospital (CA)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12916-025-04332-3
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canada Research Chairs
- Canadian Institutes of Health Research