Fe(OTf)<sub>3</sub>-Catalyzed Diastereoselective Synthesis of α-Aminophosphonates via Phosphorylation of <i>N,O</i>-Acetals
An efficient approach to α<i>-</i>aminophosphonates has been developed through an Fe(OTf)<sub>3</sub>-catalyzed <i>N-</i>α phosphonylation of <i>N,O</i>-acetals with triethyl phosphite. As a result, a series of 2,6-<i>cis</i> and 2,5-<i>trans</i> α<i>-</i>aminophosphonates were obtained in moderate to excellent yields and with excellent diastereoselectivities (<i>dr</i> up to 19:1).
Authors
- Bang‐Guo Wei (ORCID: https://orcid.org/0000-0003-3470-6741)
- Jian‐Ting Sun
- Yu Zhang (ORCID: https://orcid.org/0000-0002-2614-5975)
- Xin Li (ORCID: https://orcid.org/0009-0002-8445-5354)
- Xiaolin Liu (ORCID: https://orcid.org/0009-0000-1574-414X)
Institutions
- Fudan University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1021/acs.joc.5c01554
- Citations
- 2
- Primary Topic
- Organophosphorus compounds synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China