NFIA-dependent upregulation of SMC4 promotes metastasis and metabolic reprogramming in glioma
SMC4 drives glioma progression through dual mechanisms TGF-β/SMAD-mediated metastasis and LDHA-dependent glycolysis regulated by NFIA. This extends beyond its known role in TGF-β activation by identifying NFIA as an upstream regulator and metabolic reprogramming as a novel function. The SRRS and nomogram provide robust tools for prognosis and personalized therapy, supporting the NFIA/SMC4 axis and downstream effectors as potential therapeutic targets for glioma.
Authors
- Zewen Song (ORCID: https://orcid.org/0000-0002-9685-0725)
- Zhaoqiang Qian
- Xiaoyan Li (ORCID: https://orcid.org/0000-0003-1910-2464)
- Zhiqiang Liu (ORCID: https://orcid.org/0000-0002-7684-968X)
- Guoyin Li (ORCID: https://orcid.org/0000-0002-9148-1051)
- Yubo He
- Yukui Zhao
Institutions
- Central South University (CN)
- Shanxi Medical University (CN)
- Zhoukou Normal University (CN)
- Third Xiangya Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- Shaanxi Normal University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fonc.2025.1624370
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00