Research Progress and Future Prospects of Detection Technology Based on ctDNA methylation in Cancer detection

CtDNA methylation detection technology, as a novel tumor marker detection method, plays a significant role in cancer screening. This article summarizes the development history of ctDNA methylation detection technology, existing ctDNA methylation detection technology, and practical application cases of ctDNA methylation detection technology in cancer screening. It also analyzes the technical principles of two major existing techniques: affinity enrichment and Em-seq, as well as their respective advantages and disadvantages.