Genetic correlation and causal relationships between autoimmune thyroid disease and major depressive disorders
AITD and MDD are genetically correlated in global and local chromosomal regions. MR analyses support a putative casual effect of MDD on AITD risk, though residual pleiotropy or confounding cannot be fully excluded. These findings highlight the need for triangulation with experimental and longitudinal studies to confirm causality.
Authors
- Congqing Miao
- Dechuan Lu
- Peng Du (ORCID: https://orcid.org/0000-0002-6913-7545)
- Yang Yu (ORCID: https://orcid.org/0000-0001-8290-2080)
- Yingshuo Zhong
- Yingzi Chen (ORCID: https://orcid.org/0000-0002-6415-0011)
Institutions
- Northern Jiangsu People's Hospital (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Acta Neuropsychiatrica
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/neu.2025.10033
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cambridge