Platelet protease nexin-1 limits fibrinolysis in patients with cirrhosis
The role of PN-1, a serpin that regulates both coagulation and fibrinolysis, is unknown in cirrhosis. PN-1 appears as an important regulator of fibrinolysis in patients with cirrhosis. The role of PN-1 (and platelets more broadly) should be taken into account when assessing fibrinolysis in patients with cirrhosis.
Authors
- Marion Tanguy (ORCID: https://orcid.org/0000-0002-3927-2228)
- Stéphane Loyau (ORCID: https://orcid.org/0000-0001-8748-501X)
- François Durand (ORCID: https://orcid.org/0000-0002-0357-1090)
- Laurence Vénisse
- Audrey Payancé (ORCID: https://orcid.org/0000-0001-7978-7982)
- Véronique Arocas (ORCID: https://orcid.org/0000-0002-2872-8058)
- Emmanuelle de Raucourt (ORCID: https://orcid.org/0000-0001-8774-3162)
- Pierre‐Emmanuel Rautou (ORCID: https://orcid.org/0000-0001-9567-1859)
- Marie‐Christine Bouton (ORCID: https://orcid.org/0000-0001-5092-7363)
- Julien Bissonnette (ORCID: https://orcid.org/0000-0003-1716-416X)
- Louise Biquard (ORCID: https://orcid.org/0000-0002-1356-6543)
- Alix Riescher‐Tuczkiewicz (ORCID: https://orcid.org/0000-0002-7489-9931)
- Yacine Boulaftali (ORCID: https://orcid.org/0000-0003-4870-2098)
- Antoine Wawrzyniak
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Hôpital Beaujon (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Recherche sur l'Inflammation (FR)
- Laboratoire de Recherche Vasculaire Translationnelle (FR)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101563
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Fondation ARC pour la Recherche sur le Cancer
- Association Française pour l'Etude du Foie