A preclinical study of combined hepatic and renal artery denervation
Combined hepatic and renal denervation using the same multielectrode RF denervation system resulted in a substantial reduction in both renal and hepatic tissue NE levels that was sustained up to 28 days without collateral tissue injury. These mechanistic findings may have implications for the treatment of chronic diseases impacted by hepatic and renal sympathetic nervous system overactivity.
Authors
- Lucas Lauder (ORCID: https://orcid.org/0000-0003-1434-9556)
- Douglas A. Hettrick (ORCID: https://orcid.org/0000-0002-8957-7740)
- Felix Mahfoud (ORCID: https://orcid.org/0000-0002-4425-549X)
- Stefan Tunev (ORCID: https://orcid.org/0000-0002-6852-624X)
- Markus Peter Schlaich (ORCID: https://orcid.org/0000-0002-1765-0195)
- Eric A. Secemsky (ORCID: https://orcid.org/0000-0003-3861-3163)
- David E. Kandzari (ORCID: https://orcid.org/0000-0002-0868-6655)
- Pam R. Taub (ORCID: https://orcid.org/0000-0002-0684-0655)
- Raven Voora
- Julie Trudel
- Chelsea Ryan
Institutions
- University of North Carolina at Chapel Hill (US)
- Piedmont Atlanta Hospital (US)
- University of California San Diego (US)
- Medtronic (United States) (US)
Publication Details
- Journal
- EuroIntervention
- Published
- 2025-08-26
- DOI
- https://doi.org/10.4244/eij-d-25-00349
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00