Accuracy of genome-enabled polygenic risk score prediction of cruciate ligament rupture risk in the Labrador Retriever
Our results confirm that PRS models provide sufficient predictive accuracy for clinical application in veterinary medicine and offer a viable, early-life screening tool for personalized care and selective breeding to reduce CR incidence in high-risk breeds. Our results further confirm that CR is a complex polygenic disease in which genome-wide risk SNPs influence disease pathogenesis.
Authors
- Peter Muir (ORCID: https://orcid.org/0000-0003-0028-6005)
- Susannah J. Sample (ORCID: https://orcid.org/0000-0001-8551-7460)
- Benjamin H. Miranda (ORCID: https://orcid.org/0000-0002-6403-546X)
- Mehdi Momen (ORCID: https://orcid.org/0000-0002-2562-2741)
Institutions
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fvets.2025.1625953
- Primary Topic
- Gear and Bearing Dynamics Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Wisconsin-Madison