The peripheral PI3K/AKT/MLC signalling pathway alleviates myofascial pain in rats by inhibiting abnormal contraction at myofascial trigger points
These findings suggested that the increased expression of PI3K/p-AKT/p-MLC was related to myofascial pain in rats and that the PI3K inhibitor LY294002 might alleviate myofascial pain in rats by inhibiting abnormal contraction at MTrPs.
Authors
- Yuchang Zhu (ORCID: https://orcid.org/0000-0003-1145-6866)
- Luhua Yin (ORCID: https://orcid.org/0000-0002-5412-1612)
- Feihong Jin (ORCID: https://orcid.org/0000-0002-9403-4169)
- Yu Liu (ORCID: https://orcid.org/0000-0002-1282-4897)
- Mingyang Zhang (ORCID: https://orcid.org/0000-0003-4740-1197)
Institutions
- Qingdao University (CN)
- Xuzhou Medical College (CN)
- Tengzhou Central People's Hospital (CN)
- Taian City Central Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Molecular Pain
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1177/17448069251376205
- Primary Topic
- Myofascial pain diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00