Effect of Immunotherapy on Late Elderly Patients With Unresectable Hepatocellular Carcinoma: A Real‐World Clinical Study
Immunotherapy is effective and well-tolerated in LE patients with unresectable HCC, particularly in those with preserved liver function (mALBI grade 1/2a). Post-ICI treatment significantly benefits non-LE patients, with limited impact on LE patients, highlighting the need for therapeutic strategies based on age and liver function.
Authors
- Taro Watabe
- Kento Inada (ORCID: https://orcid.org/0000-0002-6367-6396)
- Mao Tsuchiya
- Takashi Fujii (ORCID: https://orcid.org/0009-0007-1029-7791)
- Keiichi Akahoshi (ORCID: https://orcid.org/0000-0003-3792-5659)
- Daisuke Ban (ORCID: https://orcid.org/0000-0003-0868-8519)
- Taro Shimizu (ORCID: https://orcid.org/0000-0002-3788-487X)
- Shun Kaneko (ORCID: https://orcid.org/0000-0003-2660-6580)
- Akiko Kusano‐Kitazume
- Hideki Watanabe (ORCID: https://orcid.org/0000-0002-9561-4077)
- Miyako Murakawa (ORCID: https://orcid.org/0000-0002-0468-4409)
- Mina Nakagawa (ORCID: https://orcid.org/0000-0003-1608-7676)
- Junko Fujiki
- Sei Kakinuma (ORCID: https://orcid.org/0000-0003-2193-5203)
- Kozue Uchidate
- Tsubasa Nobusawa
- Takehito Asakawa
- Shinya Oooka
- Isamu Shibata
- Fukiko Kawai‐Kitahata
- Tomohiro Mochida
- Ryuichi Okamoto (ORCID: https://orcid.org/0000-0002-7047-571X)
- Jun Tsuchiya (ORCID: https://orcid.org/0000-0001-9581-5840)
- Keiya Watakabe
- Yasuhiro Asahina (ORCID: https://orcid.org/0000-0002-9900-0064)
- Shunsuke Ueyama
- Chiaki Maeyashiki (ORCID: https://orcid.org/0000-0003-3026-7438)
- Sayuri Nitta
- Sho Watanabe (ORCID: https://orcid.org/0000-0002-2095-8190)
- Ayako Sato (ORCID: https://orcid.org/0000-0002-6387-2311)
- Hitoshi Kurata
- Masato Miyoshi
Institutions
- Tokyo Institute of Technology (JP)
- Toho University (JP)
- Tokyo Metropolitan Ohtsuka Hospital (JP)
- Tokyo Institute of Psychiatry (JP)
- Tsuchiura Kyodo General Hospital (JP)
- Toho University Omori Medical Center (JP)
- Showa General Hospital (JP)
- Tokyo Metropolitan Bokutoh Hospital (JP)
- Tokyo Metropolitan Hiroo Hospital (JP)
- JA Toride Medical Center (JP)
- Kure Kyosai Hospital (JP)
- National Hospital Organization (JP)
- Yokohama Municipal Minato Red Cross Hospital (JP)
- Yokosuka Kyosai Hospital (JP)
- Musashino Red Cross Hospital (JP)
- Tokyo Metropolitan Tama Medical Center (JP)
- National Disaster Medical Center (JP)
- Soka Municipal Hospital (JP)
- Tokyo Rosai Hospital (JP)
- Kashiwa Municipal Hospital (JP)
- Institute of Science Tokyo (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1002/cam4.71171
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science