Atypical mesenchyme in congenital pulmonary airways malformation: a promising new focus
Our study reveals the presence of abnormal mesenchyme and muscle in and surrounding cystic tissue. Despite normal lung function during pediatric follow-up, the atypical mesenchyme with possible impaired epithelial-mesenchymal transition could potentially contribute to the development of late adult pathologies such as chronic obstructive pulmonary disease or lung tumors and should be assessed accordingly.
Authors
- Christophe Delacourt (ORCID: https://orcid.org/0000-0002-0007-7150)
- Isabelle Ruchonnet-Métrailler (ORCID: https://orcid.org/0000-0003-4771-875X)
- Yannick Avila
- Marie‐Luce Bochaton‐Piallat (ORCID: https://orcid.org/0000-0001-8408-8932)
- Anne‐Laure Rougemont (ORCID: https://orcid.org/0000-0002-1785-792X)
- Anita Hiltbrunner
- P Azar
- Isabelle Vidal (ORCID: https://orcid.org/0000-0001-9156-2145)
Institutions
- University of Geneva (CH)
- Université Paris Cité (FR)
- Institut Necker Enfants Malades (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Hospital of Geneva (CH)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12931-025-03332-4
- Citations
- 1
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Université de Genève