The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians
Our findings establish RC as an independent causal CVD risk factor in East Asian ancestry individuals and highlight population-specific differences in CVD risk profiles, emphasizing the need for ethnicity-tailored prevention strategies.
Authors
- Chenhao Lin (ORCID: https://orcid.org/0000-0001-5102-801X)
- Qingxia Huang (ORCID: https://orcid.org/0000-0001-8272-0201)
- Mengyao Yu (ORCID: https://orcid.org/0000-0002-5346-535X)
- Guo‐Chong Chen (ORCID: https://orcid.org/0000-0003-1853-6244)
- Jennifer Ming Jen Wong (ORCID: https://orcid.org/0009-0000-7181-1642)
- Mingfeng Xia (ORCID: https://orcid.org/0000-0002-5650-0165)
- Wenjun Yang (ORCID: https://orcid.org/0000-0001-5671-1344)
- Huiru Tang (ORCID: https://orcid.org/0000-0002-7139-2756)
- Yan Zheng (ORCID: https://orcid.org/0000-0003-1129-3147)
- Jinran Lin (ORCID: https://orcid.org/0000-0002-5786-071X)
- Sijia Wang (ORCID: https://orcid.org/0000-0003-2573-5030)
- Xiaofeng Wang (ORCID: https://orcid.org/0000-0001-8695-5868)
- Qi Wang (ORCID: https://orcid.org/0000-0002-8159-0270)
- Jin Li (ORCID: https://orcid.org/0000-0003-2972-5892)
- Haibo Wen (ORCID: https://orcid.org/0000-0003-3658-6691)
- Yuxiang Dai (ORCID: https://orcid.org/0000-0003-2479-8996)
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Soochow University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Zhongshan Hospital (CN)
- Pudong Medical Center (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Institute of Aging (CA)
- University of Chinese Academy of Sciences (CN)
- Fujian Agriculture and Forestry University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12916-025-04329-y
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fudan University
- National Key Research and Development Program of China
- Program of Shanghai Academic Research Leader
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning