Cranial base synostosis in mice caused by upregulation of Wnt following partial inhibition of Shh
The present experiment suggests that early activation of Shh standardizes normal embryonic development of cranial base after initial morphogenesis, which may be mediated through the "antagonistic" effect of Shh signaling on Wnt signaling. Our study provides new insights into the role of signal-crosstalk in early morphogenesis of the cranial base.
Authors
- Chuanqing Mao (ORCID: https://orcid.org/0000-0002-4214-3531)
- Yongzhen Lai
- Weihui Chen (ORCID: https://orcid.org/0000-0002-9778-4926)
- Chengyan Ren
- Jiangping Chen (ORCID: https://orcid.org/0000-0003-1370-7550)
- Meng Lü (ORCID: https://orcid.org/0000-0001-9311-2666)
- Yuanjing Jiang
Institutions
- Fujian Medical University (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12915-025-02381-x
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China