Extracellular vesicles enriched with miR-486 from Tetramethylpyrazine-preconditioned bone marrow mesenchymal stem cells promote microglia/macrophage M2 polarization and enhance neurogenesis in rats with ischemic stroke
TMP-BMSC-EVs could significantly promote neural repair by driving microglia/macrophage M2 polarization and enhancing neurogenesis through miR-486-mediated PTEN inhibition, thereby offering a promising treatment strategy for IS.
Authors
- Huiqin Hu
- Lanxi Xu
- Lisheng Chu (ORCID: https://orcid.org/0000-0001-5149-5881)
- Yimei Sun
- Jiadong Xu (ORCID: https://orcid.org/0009-0005-0463-9199)
- Shihui Mao (ORCID: https://orcid.org/0000-0001-6282-4652)
- Li Lin (ORCID: https://orcid.org/0000-0003-3355-6139)
- Weifeng Jiang (ORCID: https://orcid.org/0009-0001-2195-2225)
- Ting Lan (ORCID: https://orcid.org/0000-0002-6115-9053)
- Yan Fang (ORCID: https://orcid.org/0000-0001-9645-3888)
- Yan Feng
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s13287-025-04574-1
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Zhejiang Province Public Welfare Technology Application Research Project