Copper-Mediated <i>ortho</i>-Selective C(sp<sup>2</sup>)–H Functionalization of Carboxylic Acid Derivatives with N(sp<sup>2</sup>)–H Sulfonimidamides: A Mild and General Strategy for C–N Bond Formation
Herein, we report the copper (Cu)-mediated <i>ortho<i>-</i></i>selective C-H bond functionalization of easily accessible N(sp<sup>2</sup>)-aryl derivatives of hexavalent, diazaanalogs of sulfones such as sulfonimidamides (SIAs) with carboxylic acid derivatives decorated with oxazolidine. The <i>ortho</i>-C-H bonds of aryl amides underwent a smooth reaction with the N(sp<sup>2</sup>)-H bonds of a variety of sulfonimidamides (SIAs). The reaction offers a broad array of C-N(sp<sup>2</sup>) bond derivatives with good functional group tolerance in good yields under mild reaction conditions in an <i>ortho<i>-</i></i>selective manner.
Authors
- Jagadeesh Babu Nanubolu (ORCID: https://orcid.org/0000-0002-1677-2975)
- Srinivas Ambala
- Bathini Nagendra Babu (ORCID: https://orcid.org/0000-0001-7378-0878)
- Raga Chaitanya Kalakonda
Institutions
- North China Institute of Science and Technology (CN)
- North East Institute of Science and Technology (IN)
- Analytical Services (US)
- Structural Analytics (United States) (US)
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1021/acs.orglett.5c02464
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Council of Scientific and Industrial Research, India