Enhanced glycolysis is associated with aggressive tumor phenotype and worse outcomes in hepatocellular carcinoma patients
Elevated glycolysis signaling is linked to enhanced malignant pathways, genomic instability, and worse clinical outcomes in HCC, indicating its potential as a prognostic biomarker.
Authors
- Masanori Oshi
- Itaru Endo (ORCID: https://orcid.org/0000-0001-5520-8114)
- Kazuaki Takabe (ORCID: https://orcid.org/0000-0002-6435-4241)
- Colin J. Rog (ORCID: https://orcid.org/0000-0002-7834-1417)
- Yan Li (ORCID: https://orcid.org/0000-0002-7058-3569)
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Fukushima Medical University (JP)
- Niigata University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-26
- DOI
- https://doi.org/10.3389/fmed.2025.1588604
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- National Institutes of Health