BUB1-based risk model predicts prostate cancer prognosis and reveals therapeutic vulnerabilities
After external validation, a BUB1-based four-gene prognostic signature, which may represent a subtype of PCA with more aggressive and metastatic characteristics, was shown to accurately predict the prognosis of PCA. In vitro experiments revealed that the BUB1 gene significantly affects the proliferation, invasion, and expression of specific EMT-related proteins in PCA cells.
Authors
- Huimin Hou (ORCID: https://orcid.org/0000-0001-8142-2982)
- Xingbo Long (ORCID: https://orcid.org/0000-0002-5918-687X)
- Jianye Wang (ORCID: https://orcid.org/0000-0001-5534-2727)
- Shuhang Luo
- Haoran Wang (ORCID: https://orcid.org/0009-0006-1408-3363)
- Ming Liu (ORCID: https://orcid.org/0000-0002-4770-4449)
- Jiong Zhang (ORCID: https://orcid.org/0000-0003-3578-416X)
- Runhua Tang (ORCID: https://orcid.org/0000-0002-8303-7866)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s40001-025-03098-x
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Key Research and Development Program of China