Leukemia inhibitory factor promotes human cholangiopathies, and its inhibition improves cholestasis in Abcb4 −/− mice
Cholangiocyte-derived LIF promotes the formation of a pro-inflammatory and pro-fibrotic niche centred on damaged cholangiocytes. LIFR antagonism reverses fibrosis and immune dysregulation in Abcb4-/- mice, supporting the development of anti-LIFR therapies in human cholangiopathies.
Authors
- Ginevra Urbani (ORCID: https://orcid.org/0009-0008-7461-1046)
- Cristina Di Giorgio (ORCID: https://orcid.org/0000-0001-7125-8963)
- Rachele Del Sordo (ORCID: https://orcid.org/0000-0003-3930-2957)
- Elena Giannelli
- Carmen Massa
- Massimo Del Sette (ORCID: https://orcid.org/0000-0002-4551-0675)
- Ainhoa Lapitz (ORCID: https://orcid.org/0000-0002-7928-5760)
- Malgorzata Milkiewicz
- Silvia Marchianò (ORCID: https://orcid.org/0000-0001-6198-518X)
- Maria Chiara Monti (ORCID: https://orcid.org/0000-0002-1337-2909)
- Martina Bordoni
- Luigi Cari (ORCID: https://orcid.org/0000-0003-0698-3872)
- Eleonora Distrutti
- Stefano Fiorucci (ORCID: https://orcid.org/0000-0003-3816-4222)
- Michele Biagioli (ORCID: https://orcid.org/0000-0002-2995-6896)
- Valentina Sepe (ORCID: https://orcid.org/0000-0002-0169-4441)
- Angela Zampella (ORCID: https://orcid.org/0000-0002-6170-279X)
- Jesús M. Bañales (ORCID: https://orcid.org/0000-0002-5224-2373)
- Piotr Milkiewicz (ORCID: https://orcid.org/0000-0002-1817-0724)
- Elva Morretta (ORCID: https://orcid.org/0000-0002-7244-0297)
- Ginevra Lachi
- Rosa De Gregorio
- Francesca Paniconi
- Benedetta Sensini
Institutions
- Ikerbasque (ES)
- Medical University of Warsaw (PL)
- University of Perugia (IT)
- Azienda Ospedaliera di Perugia (IT)
- Centro Ricerche Produzioni Animali (IT)
- Biogipuzkoa Health Research Institute (ES)
- University of Naples Federico II (IT)
- Pomeranian Medical University (PL)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1097/hc9.0000000000000779
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00