Leukemia inhibitory factor promotes human cholangiopathies, and its inhibition improves cholestasis in Abcb4 −/− mice

Cholangiocyte-derived LIF promotes the formation of a pro-inflammatory and pro-fibrotic niche centred on damaged cholangiocytes. LIFR antagonism reverses fibrosis and immune dysregulation in Abcb4-/- mice, supporting the development of anti-LIFR therapies in human cholangiopathies.

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Publication Details

Journal
Hepatology Communications
Published
2025-08-26
DOI
https://doi.org/10.1097/hc9.0000000000000779
Primary Topic
Liver Diseases and Immunity
Type
article
Field-Weighted Citation Impact
0.00
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article

Leukemia inhibitory factor promotes human cholangiopathies, and its inhibition improves cholestasis in Abcb4 −/− mice

Ginevra Urbani, Cristina Di Giorgio, Rachele Del Sordo, Elena Giannelli et al.
Hepatology Communications
Liver Diseases and Immunity
article

Leukemia inhibitory factor promotes human cholangiopathies, and its inhibition improves cholestasis in Abcb4 −/− mice

Ginevra Urbani, Cristina Di Giorgio, Rachele Del Sordo, Elena Giannelli, Carmen Massa, Massimo Del Sette, Ainhoa Lapitz, Malgorzata Milkiewicz, Silvia Marchianò, Maria Chiara Monti, Martina Bordoni, Luigi Cari, Eleonora Distrutti, Stefano Fiorucci, Michele Biagioli, Valentina Sepe, Angela Zampella, Jesús M. Bañales, Piotr Milkiewicz, Elva Morretta, Ginevra Lachi, Rosa De Gregorio, Francesca Paniconi, Benedetta Sensini
article en

Abstract

Cholangiocyte-derived LIF promotes the formation of a pro-inflammatory and pro-fibrotic niche centred on damaged cholangiocytes. LIFR antagonism reverses fibrosis and immune dysregulation in Abcb4-/- mice, supporting the development of anti-LIFR therapies in human cholangiopathies.

Hepatology CommunicationsVol. 9(9)
Ikerbasque (ES), Medical University of Warsaw (PL), University of Perugia (IT), Azienda Ospedaliera di Perugia (IT), Centro Ricerche Produzioni Animali (IT), Biogipuzkoa Health Research Institute (ES), University of Naples Federico II (IT), Pomeranian Medical University (PL), Universidad de Navarra (ES)
Openalex Percentile: Top 69%
Liver Diseases and Immunity
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