Neuropeptide Precursor VGF Promotes Neuroendocrine Differentiation and Cancer-Associated Fibroblast Activation in Small Cell Lung Cancer
VGF is a therapeutic target in small cell lung cancer that promotes expression of ASCL1 to drive neuroendocrine differentiation and mediates lactate exchange between cancer cells and fibroblasts in the tumor microenvironment.
Authors
- Guopin Liu (ORCID: https://orcid.org/0009-0002-8721-9517)
- Jianshan Mo (ORCID: https://orcid.org/0000-0001-9759-4447)
- Yingxue Su (ORCID: https://orcid.org/0000-0002-4200-2202)
- Jiayu Yan (ORCID: https://orcid.org/0009-0000-1858-6749)
- Jianzheng Zhu (ORCID: https://orcid.org/0009-0006-3160-4554)
- Xiaolei Zhang (ORCID: https://orcid.org/0000-0003-2395-2453)
- Menghan Xue (ORCID: https://orcid.org/0009-0008-8349-1090)
- Peibin Yue (ORCID: https://orcid.org/0000-0001-6328-8441)
- Shumin Ouyang (ORCID: https://orcid.org/0000-0001-7629-9326)
- Yanyan Wu (ORCID: https://orcid.org/0000-0003-1451-4603)
- Jin‐Jian Lu (ORCID: https://orcid.org/0000-0001-6703-3120)
- Libin Wang (ORCID: https://orcid.org/0000-0002-7861-1560)
- Danyuan Sun (ORCID: https://orcid.org/0009-0000-2888-3886)
- Jiangling Ye (ORCID: https://orcid.org/0009-0005-0615-6000)
- Wen Ding (ORCID: https://orcid.org/0009-0004-7548-5724)
- Yandong Wang (ORCID: https://orcid.org/0009-0005-4068-6689)
Institutions
- Cedars-Sinai Medical Center (US)
- Union Hospital (HK)
- Sun Yat-sen University (CN)
- Guangdong Pharmaceutical University (CN)
- University of Macau (MO)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0405
- Citations
- 3
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.14