Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort

Our results provide evidence for neuroanatomical correlates of the NAPLS-2 model, with alterations in hippocampal circuits suggesting a key prognostic role in the development of neurocognitive and psychosocial deficits across diagnostic boundaries. Future longitudinal studies incorporating multimodal imaging techniques should validate these findings as potential biomarkers for psychosis risk.

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Publication Details

Journal
Schizophrenia Bulletin
Published
2025-08-26
DOI
https://doi.org/10.1093/schbul/sbaf135
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort

Leonardo Fazio, Maria Nobile, Marian Surmann, Otto Turtonen et al.
Schizophrenia Bulletin
Schizophrenia research and treatment
article

Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort

Leonardo Fazio, Maria Nobile, Marian Surmann, Otto Turtonen, Anna Toivonen, Alessandro Bertolino, Ruth Milz, María Fernanda Urquijo, Christina Andreou, Nora Penzel, Ileana Andriola, Antti Luutonen, Giuseppe Blasi, Norman Kluthausen, Ashleigh Lin, Christos Pantelis, Janina Paju, Giampaolo Perna, Akseli Mäkela, Martina Wassen, Franco Fabbro, Sebastian von Saldern, Ifrah Khanyaree, Johanna Weiske, Anu Ellilä, Mirabel Pelton, Yanis Köhler, Karsten Blume, Sara Piccin, Amatya Mackintosh, Manuela Abraham, Lana Kambeitz‐Ilankovic, Stephen James Wood, Dominic Dwyer, Alexandra Nikolaides, Päivi Jalo, Chris Day, Matteo Balestrieri, Laura Egloff, Tiziana Quarto, Raffaella Romano, Heikki Laurikainen, Alexander Denissoff, Erich Studerus, Markus Heinimaa, Giuseppe Cabras, Pavan Mallikarjun, Αλεξάνδρα Κορδά, Theresa Lichtenstein, Mauro Seves, Lisa Hahn, Antonia Wosgien, David Popovic, Aylin Melo, Mariam Iqbal, Carlo Altamura, Carolina Bonivento, Tiina From, Moritz Spangemacher, Giulio Pergola, Armando D’Agostino, Nathalie Kaiser, Lorenzo Del Fabro, Alessandra Alciati, Marco Garzitto, Henri Pesonen, Tuula Ilonen, Rachel Upthegrove, Francesca Bottinelli, Emiliano Monzani, Fabienne Harrisberger, Hans‐Jörg Wittsack, Adrian Rangnick, Maurizio Sberna, Shalaila S. Haas, Dennis M. Hedderich, Gerald Antoch, Paolo Brambilla, Olga Bienek, Letizia Leanza, Claudia Lenz, Raimo K. R. Salokangas, Andrea Falsetti, Marina Sangiuliano, Jarmo Hietala, Sonja Widmayer, Claudius Hoff, Adele Ferro, Timo Schirmer, Marta Re, Susanna Muckenhuber-Sternbauer, Tanja Pilgram, Peter Falkai, Camilla Krämer, Sonja Botterweck, Ana Beatriz Solana, Rachele Sanfelici, Dominika Julkowski, L. Neuner, Linda A. Antonucci, Stefan Borgwardt, Marika Belleri, Alexandra Stainton, Renata Smieskova, Joseph Kambeitz, Julian Caspers, Ana Tupac, Roberta Passiatore, Siân Lowri Griffiths, Reetta-Liina Säilä, Tyrone D. Cannon, Ulrike Heitz, Nikolaos Koutsouleris, Rebekka Lencer, Anna Walter, Alkomiet Hasan, Marina Barone, Barbara Gelao, Grazia Caforio, Eva Meisenzahl, Udo Dannlowski, Georg Romer, Oemer Faruk Oeztuerk, Clara Weyer
article en

Abstract

Our results provide evidence for neuroanatomical correlates of the NAPLS-2 model, with alterations in hippocampal circuits suggesting a key prognostic role in the development of neurocognitive and psychosocial deficits across diagnostic boundaries. Future longitudinal studies incorporating multimodal imaging techniques should validate these findings as potential biomarkers for psychosis risk.

Schizophrenia Bulletin
University of Turku (FI), King's College London (GB), University of Basel (CH), University of Milan (IT), University of Münster (DE), Turku University Hospital (FI), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Warneford Hospital (GB), LMU Klinikum (DE), Yale University (US), University of Oxford (GB), Orygen Youth Health (AU), University Hospital Münster (DE), St. George's School (US), Orygen (AU), German Center for Infection Research (DE), Bernstein Center for Computational Neuroscience Munich (DE), Max Planck Institute of Psychiatry (DE), International Max Planck Research School for Advanced Methods in Process and Systems Engineering (DE), University Hospital Cologne (DE), Melbourne Health (AU), Heinrich Heine University Düsseldorf (DE), University of Bari Aldo Moro (IT), University of Birmingham (GB), Ludwig-Maximilians-Universität München (DE), University of Lübeck (DE)
Wellcome Trust
Openalex Percentile: Top 74%
Schizophrenia research and treatment
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