Late-Onset Neutropenia in Clozapine Users: Unrelated or Drug-Induced? A Case-Registry Analysis of Incidence, Characteristics, and Rechallenge Attempts
Though less frequent, late-onset SBD shares similar characteristics with early-onset SBD and has a comparable risk of recurrence on clozapine rechallenge. Vast majority of clozapine rechallenges are successful, including early-onset BD, suggesting they are not clozapine-induced. However, clozapine-induced BD, defined by recurrence upon rechallenge, may rarely occur even after years of treatment.
Authors
- Amelia Jewell (ORCID: https://orcid.org/0000-0002-0887-2159)
- Risha Govind (ORCID: https://orcid.org/0000-0001-9925-7866)
- David P. Taylor (ORCID: https://orcid.org/0000-0001-9759-4084)
- Cecilia Casetta (ORCID: https://orcid.org/0000-0002-1980-3415)
- Matthew Broadbent
- Aviv Segev (ORCID: https://orcid.org/0000-0002-9550-3895)
- Megan Pritchard (ORCID: https://orcid.org/0000-0001-8872-3614)
- Ebenezer Oloyede (ORCID: https://orcid.org/0000-0003-1352-4017)
- James Hunter MacCabe (ORCID: https://orcid.org/0000-0002-6754-1018)
- Harsimran Kaur Makan
Institutions
- Tel Aviv University (IL)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- University of Oxford (GB)
- NIHR Maudsley Dementia Biomedical Research Unit (GB)
- Shalvata Mental Health Center (IL)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1093/schbul/sbaf148
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- H. Lundbeck A/S