Gender-specific associations of blood immune markers with symptoms and cognitive function in major depressive disorder: a cross-sectional observational study
Immune dysregulation in MDD was associated with emotional symptoms and cognitive impairment. Inflammatory markers correlated with attention, executive function and working memory in males, whereas in females, they were linked to subjective cognition, executive function, and composite cognition. Gender differences should be considered in immune-cognitive interactions, which may inform personalized therapeutic interventions.
Authors
- Yajuan Fan (ORCID: https://orcid.org/0000-0002-8783-5582)
- Xianyan Zhan
- Xiancang Ma (ORCID: https://orcid.org/0000-0002-7826-305X)
- Yuan Gao (ORCID: https://orcid.org/0009-0004-1968-0648)
- Ding Yang (ORCID: https://orcid.org/0000-0002-0854-8287)
- Min Jia (ORCID: https://orcid.org/0000-0002-3213-7285)
- Qingyan Ma
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12888-025-07277-2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Xi’an Jiaotong University
- Key Research and Development Projects of Shaanxi Province