Association of maternal infections, antibiotic use, and cesarean delivery with the risk of early-onset sepsis: a nationwide population-based study in full-term neonates
This study provides the most comprehensive analysis to date of EOS risk in term neonates using a nationwide dataset. Our findings indicate that cesarean delivery, maternal antibiotic use, specific maternal infections, maternal diabetes mellitus, premature rupture of membranes, and lower birth weight are associated with an increased risk of EOS. Further research is warranted to explore the potential causal relationships underlying these associations.
Authors
- Ming‐Luen Tsai (ORCID: https://orcid.org/0000-0002-3727-7033)
- Shu‐Hua Ko
- Hao-Yuan Lee (ORCID: https://orcid.org/0000-0001-7401-856X)
- Yu‐Lung Hsu (ORCID: https://orcid.org/0000-0002-3010-2767)
- Horng-Chyuan Lin (ORCID: https://orcid.org/0000-0002-1830-1819)
- Yu-Chia Chang (ORCID: https://orcid.org/0000-0002-7347-0615)
- Yu-Ling Huang (ORCID: https://orcid.org/0000-0002-8288-1627)
- Hung‐Chih Lin (ORCID: https://orcid.org/0000-0002-8111-8371)
- Chyi-Liang Chen
- Wen-Yuan Lee
Institutions
- Fu Jen Catholic University (TW)
- Asia University (TW)
- National Quemoy University (TW)
- China Medical University (TW)
- Chang Gung Memorial Hospital (TW)
- Ministry of Health and Welfare (TW)
- China Medical University Hospital (TW)
- Mackay Junior College of Medicine, Nursing and Management (TW)
- Taichung Hospital (TW)
- Kang-Ning Junior College of Medical Care and Management (TW)
- Memorial Hospital (US)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s12884-025-08031-y
- Citations
- 2
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- China Medical University Hospital
- China Medical University
- Health and Welfare Data Science Center
- Division of Materials Research