Expression of thrombospondin-4 in the infrapatellar fat pad and synovial fluid – potential contribution to osteoarthritis pain
TSP-4 has been detected in the IFP for the first time. The correlation between TSP-4 expression and fibrotic severity indicates a possible involvement of TSP-4 in the development of fibrosis. Although TSP-4 within the IFP may not directly mediate pain, its presence in synovial fluid could be of functional relevance in pain-related mechanisms. Further analysis of synovial fluid and even serum samples from larger patient populations will determine whether TSP-4 could serve as a biomarker for pain or potentially represent a novel target for analgesic therapies.
Authors
- Rebecca Sohn (ORCID: https://orcid.org/0009-0003-1299-8699)
- Gundula Rösch (ORCID: https://orcid.org/0000-0002-9095-3950)
- Anna E. Rapp (ORCID: https://orcid.org/0000-0001-5122-765X)
- Sebastian Braun (ORCID: https://orcid.org/0000-0003-4175-8718)
- Frank Zaucke (ORCID: https://orcid.org/0000-0002-7680-9354)
- Zsuzsa Jenei‐Lanzl (ORCID: https://orcid.org/0000-0003-2586-2523)
- Patrizia Pollinger
Institutions
- Goethe University Frankfurt (DE)
- Humboldt-Universität zu Berlin (DE)
- University Hospital Frankfurt (DE)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s13075-025-03615-7
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Deutsche Forschungsgemeinschaft