Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Opioids are frequently overprescribed after surgery. We applied a tabular foundation model to predict the risk of post-discharge opioid consumption. The model was trained and internally validated on an 80:20 training/test split of the 'Opioid PrEscRiptions and usage After Surgery' (ACTRN12621001451897p) study cohort, including adult patients undergoing general, orthopaedic, gynaecological and urological operations (n = 4267), with external validation in a distinct cohort of patients discharged after general surgical procedures (n = 826). The area under the receiver operator curve was 0.84 (95% confidence interval [CI] 0.81-0.88) at internal testing and 0.77 (95% CI 0.74-0.80) at external validation. Brier scores were 0.13 (95% CI 0.12-0.14) and 0.19 (95% CI 0.17-0.2). Patients with a <50% predicted risk of opioid consumption consumed a median of 0 oral morphine equivalents in the first week after surgery. Applying this model would reduce opioid prescriptions by 4.5% globally, and counterfactual modelling suggests without increasing time in severe pain (-4.3%, 95% CI -17.7 to 8.6).

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Journal
npj Digital Medicine
Published
2025-08-26
DOI
https://doi.org/10.1038/s41746-025-01798-6
Primary Topic
Opioid Use Disorder Treatment
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article
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0.00

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article

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

David Singer, Andi Lu, Omar Hamdy, Fatima Mustafa et al.
npj Digital Medicine
Opioid Use Disorder Treatment
article

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

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Swansson, Daniel Abulafia, Katie Van Zuylekom, Kate Van Zuylekom, Jazmina Tarmidi, Mahmoud Ugool, Leshya Naiker, Armitesh Nagaratnam, Mohamed Haseef Mohamed Yunos, Rachel Phu, Aki Flame, Elizabeth Crostella, Sriya Bobba, Yin Chi Hebe Hau, Emily Heaney, Akeedh Razmi, Prasanna Pothukuchi, Matthew Clanfield, Rami Dennaoui, Kristian Baziotis-Kalfas, Hannah Denby, Rana Abdelmeguid, Xireaili Feierdaiweisi, Sasini Vidanagama, Tharushi Sampatha-Waduge, Chatnapa Yodkitydomying, Julia Silverii, Ridvan Atilhan, Kristina Vanguardia, Hodo Haximolla, Danielle Chéné, Philip Jakanovski, Pattarapan Tang-Ieam, Damian Golja, Amy Gojnich, Luca Burruso, Nathan Mcorist, Daniel Mauricio Bolanos Nanez, Donia Eldomiaty, Rawan Rafaei, Youssef Elghoul, Yousef Tarek, Zeyad Haggag, Dina Atef, Mostafa Abdelbaky, Ahmed Shipa, Samah Abdelnaeam, Fady Barsoum, Doaa Abdelbaset, Nour Salah Khairallah, Enas Abdelbaset Abdelsamed, Esraa Hamoda, Fatma Harb, Kerollos Henes, Ola Haroon, Tarek A Hussien, George Sobhy, Osama Fathy Ali Ali Rashed, Bassant Maged Maged, Bassma Raslan, Eman Teema, Asmaa Deafallah, Rabiaa Alomar, Issa AbuShawareb, Georgios Korovesis, Olga Maria Valaroutsou, Stergios Kopatsaris, Apostolos Champipis, Fragkiskos Angeslis, Mohammed Khorsheed, Giulia Giuzzardi, Farah Banihani, Nada Massadeh, Dima Al-issawi, Basel Elyan, Qotadah Al-Shami, Gopal Singh, A Youssef, Arfaan Sheriff, James Fung, Uzair Ahmed, Mohamd A. A. Alkchr, Mahammed Aldreawi, Sharifah Nor Amirah Syed Abdul Lati Alsagoff, Doha Amir AtaAlmanan, men Roshdy, Mohammed Fargaly, Reham Silem, Ahmed Zaharia, Mohammed Attiah, Abdalqader Al Smadi, ath Al-Hazaimeh
article en

Abstract

Opioids are frequently overprescribed after surgery. We applied a tabular foundation model to predict the risk of post-discharge opioid consumption. The model was trained and internally validated on an 80:20 training/test split of the 'Opioid PrEscRiptions and usage After Surgery' (ACTRN12621001451897p) study cohort, including adult patients undergoing general, orthopaedic, gynaecological and urological operations (n = 4267), with external validation in a distinct cohort of patients discharged after general surgical procedures (n = 826). The area under the receiver operator curve was 0.84 (95% confidence interval [CI] 0.81-0.88) at internal testing and 0.77 (95% CI 0.74-0.80) at external validation. Brier scores were 0.13 (95% CI 0.12-0.14) and 0.19 (95% CI 0.17-0.2). Patients with a <50% predicted risk of opioid consumption consumed a median of 0 oral morphine equivalents in the first week after surgery. Applying this model would reduce opioid prescriptions by 4.5% globally, and counterfactual modelling suggests without increasing time in severe pain (-4.3%, 95% CI -17.7 to 8.6).

npj Digital MedicineVol. 8(1)
University of Aleppo (SY), Suez Canal University (EG), Griffith University (AU), Australian National University (AU), Hebron University (PS), Texas Tech University (US), Trakya University (TR), Camden and Campbelltown Hospitals (AU), University of Udine (IT), The University of Sydney (AU), University of Tasmania (AU), New South Wales Department of Health (AU), Ekiti State University (NG), Lehigh Valley Hospital-Pocono (US), Royal Adelaide Hospital (AU), The Royal Melbourne Hospital (AU), Izmir University (TR), Box Hill Hospital (AU), King Edward Medical University (PK), Deakin University (AU), Misurata University (LY), University of Cauca (CO), University of Auckland (NZ), Nil Ratan Sircar Medical College and Hospital (IN), Mansoura University (EG), Karadeniz Technical University (TR), Ufuk University (TR), Universidad Autónoma de Nuevo León (MX), Flinders University (AU), Abubakar Tafawa Balewa University (NG), The University of Western Australia (AU), Alzaiem Alazhari University (SD), Zagazig University (EG), Dokuz Eylül University (TR), Mutah University (JO), University of Tripoli (LY), Hitit Üniversitesi (TR), Goulburn Base Hospital (AU), Royal Prince Alfred Hospital (AU), Royal Perth Hospital (AU), Lahore General Hospital (PK), Queen Elizabeth II Jubilee Hospital (AU), Gold Coast Hospital (AU), Jordan Hospital (JO), Tripoli Central Hospital (LY), King Abdullah University Hospital (JO), Palestinian Hydrology Group (PS), Middlemore Hospital (NZ), Austin Hospital (AU), John Hunter Hospital (AU), Civil Hospital Karachi (PK), Logan Hospital (AU), King Saud Medical City (SA), Wellington Hospital (NZ), Gosford Hospital (AU), Hunter Water (AU), Women's and Children's Hospital (AU), Monash Medical Centre (AU), Wollongong Hospital (AU), Auckland City Hospital (NZ), Waikato Hospital (NZ), Lyell McEwin Hospital (AU), Frankston Hospital (AU), The Alfred Hospital (AU), North Shore Hospital (NZ), Sir Charles Gairdner Hospital (AU), Services Hospital (PK), Dunedin Public Hospital (NZ), Christchurch Hospital (NZ), Northern Hospital (AU), Aga Khan University Hospital (PK), Flinders Medical Centre (AU), Canberra Hospital (AU), Westmead Hospital (AU), Afe Babalola University (NG), Kaduna State University (NG), Bezmiâlem Vakıf Üniversitesi (TR), Istanbul Medipol University (TR), National Ribat University (SD), Korean Council for University Education (KR), University of Benghazi (LY), Klaipėda University (LT), Palestine Polytechnic University (PS), Auckland University of Technology (NZ), University Ferhat Abbas of Setif (DZ), Institutul Regional de Oncologie (RO), Moscow City Hospital No 29 (RU), Tanta University Hospital (EG), Hospital Universiti Sains Malaysia (MY), Mansoura University Hospital (EG), Northland District Health Board (NZ), Department of the Premier and Cabinet (AU), Gaziantep Children's Hospital (TR), Lehigh Valley Health Network (US), Latrobe Regional Hospital (AU), Tauranga Hospital (NZ), Azienda Unità Sanitaria Locale di Ferrara (IT), Queen Elizabeth Hospital (AU), Centre Hospito Universitaire de Sétif (DZ), Rotorua Hospital (NZ), Ipswich Hospital (AU), Sunshine Coast University Hospital (AU), Western NSW Local Health District (AU), Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR), Clinical Hospital No. 8 (RU), Atrium Medical Cente (US), Stanford Health Care (US), University Hospital of Larissa (GR), Ballarat Health Services (AU), Sina Hospital (IR), Bowral & District Hospital (AU), Istanbul University-Cerrahpaşa (TR), Counties Manukau District Health Board (NZ), Laiko General Hospital of Athens (GR), Samsun University (TR), Western Health (AU), Ippokrateio General Hospital of Thessaloniki (GR), WA Country Health Service (AU), Albury Wodonga Health (AU), Northern Sydney Local Health District (AU), Azienda USL di Bologna (IT), Hospital Arnau de Vilanova (ES), Lishman Health Foundation (AU), Istituto Ortopedico Rizzoli (IT), St Savas Hospital (GR), Assiut University Hospitals (EG), Gazi Hastanesi (TR), Mayo Clinic in Arizona (US), Western Regional Hospital (NP), University of Abuja Teaching Hospital (NG), Sağlık Bilimleri Üniversitesi (TR), Hospital Universitario Dr José Eleuterio Gonzalez (MX), City Clinical Hospital (RU), Ospedale L. Bonomo (IT), Sudan Medical Specialization Board (SD), St John of God Hospital (AU), IASO General Hospital (GR), Mayo Clinic in Florida (US), Taranaki Base Hospital (NZ), Hospital General de Elda (ES), University of Bahri (SD), Hospital Universitari Sant Joan de Reus (ES), Southland Hospital (NZ), Melbourne Clinic (AU), Ibn Sina Hospital (KW), University of Ilorin Teaching Hospital (NG), Hunter New England Local Health District (AU), Phipps Houses (US), G. Papanikolaou General Hospital (GR), Republic Klaipeda Hospital (LT), Médecins Sans Frontières (JO), First Affiliated Hospital of Jinan University (CN), Plymouth Hospital (GB), İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi (TR), Hospital Fatuma Bourguiba Monastir (TN), Armadale Health Service, Royal Australasian College of Surgeons (AU), Monash University (AU), The University of Adelaide (AU), Gadarif University (SD), Modibbo Adama University of Technology (NG), Western Sydney University (AU), Menoufia University (EG), Medical College and Hospital, Kolkata (IN), Marmara University (TR), ZTE (United States) (US), University of Newcastle Australia (AU), Muğla University (TR), University of Otago (NZ), Universiti Teknologi MARA (MY), Alexandria University (EG), Poultry CRC (AU), Aswan University (EG), Port Said University (EG), Texas Tech University Health Sciences Center (US), University of Edinburgh (GB)
Maurice and Phyllis Paykel Trust, University of Newcastle Australia, Health Research Council of New Zealand
Openalex Percentile: Top 70%
Opioid Use Disorder Treatment
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