Single-Cell and Plasma Proteomics Do Not Differentiate Patients With and Without SARS-CoV-2 Antigenemia in Convalescence in a Cohort of 100 Patients
Plasma samples obtained approximately 3 (<i>n</i> = 100) and 12 months (<i>n</i> = 78) after acute SARS-CoV-2 infection were tested for S1, spike, and N antigens. There were no significant differences in plasma proteins or single-cell protein expression levels on immune cells between those with and without plasma antigen detected.
Authors
- Rebecca E. Hamlin (ORCID: https://orcid.org/0000-0001-7336-6028)
- Prasanna Jagannathan (ORCID: https://orcid.org/0000-0001-6305-758X)
- Zoe Swank (ORCID: https://orcid.org/0000-0001-8825-0335)
- Karen B. Jacobson (ORCID: https://orcid.org/0000-0003-3050-4595)
- Phillip Grant (ORCID: https://orcid.org/0000-0001-7077-8756)
- Hector Fabio Bonilla (ORCID: https://orcid.org/0000-0002-0513-8733)
- Upinder Singh (ORCID: https://orcid.org/0000-0003-0630-0306)
- Aruna Subramanian (ORCID: https://orcid.org/0000-0002-1373-6768)
- Catherine A. Blish (ORCID: https://orcid.org/0000-0001-6946-7627)
- David R. Walt (ORCID: https://orcid.org/0000-0002-5524-7348)
- S. Pienkos
- Mallika Rao (ORCID: https://orcid.org/0009-0007-5069-0117)
Institutions
- University of Iowa (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Chan Zuckerberg Initiative (United States) (US)
- Stanford Medicine (US)
- Center for Clinical Research (United States) (US)
- Inspire Institute (US)
- Stanford University (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1093/ofid/ofaf515
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Heart, Lung, and Blood Institute