Identification of core genes in the extracellular matrix and the regulatory mechanisms of the immune microenvironment in idiopathic pulmonary fibrosis using WGCNA and machine learning methods

BAAT, COMP, and CXCL13 may serve as potential therapeutic targets for slowing the progression and preventing the exacerbation of IPF. Moreover, monocytes demonstrate consistent infiltration patterns across the disease group, control group, and various subgroups, indicating their potential significance in the development of IPF.

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Publication Details

Journal
PLoS ONE
Published
2025-08-26
DOI
https://doi.org/10.1371/journal.pone.0330725
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
0.00

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article

Identification of core genes in the extracellular matrix and the regulatory mechanisms of the immune microenvironment in idiopathic pulmonary fibrosis using WGCNA and machine learning methods

Shihuan Yu, Yang Liu, Lu Liu, M. Wang
PLoS ONE
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
article

Identification of core genes in the extracellular matrix and the regulatory mechanisms of the immune microenvironment in idiopathic pulmonary fibrosis using WGCNA and machine learning methods

Shihuan Yu, Yang Liu, Lu Liu, M. Wang
article en

Abstract

BAAT, COMP, and CXCL13 may serve as potential therapeutic targets for slowing the progression and preventing the exacerbation of IPF. Moreover, monocytes demonstrate consistent infiltration patterns across the disease group, control group, and various subgroups, indicating their potential significance in the development of IPF.

PLoS ONEVol. 20(8)
Harbin Medical University (CN), First Affiliated Hospital of Harbin Medical University (CN)
Wu Jieping Medical Foundation
Openalex Percentile: Top 67%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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