Identification of core genes in the extracellular matrix and the regulatory mechanisms of the immune microenvironment in idiopathic pulmonary fibrosis using WGCNA and machine learning methods
BAAT, COMP, and CXCL13 may serve as potential therapeutic targets for slowing the progression and preventing the exacerbation of IPF. Moreover, monocytes demonstrate consistent infiltration patterns across the disease group, control group, and various subgroups, indicating their potential significance in the development of IPF.
Authors
- Shihuan Yu
- Yang Liu (ORCID: https://orcid.org/0000-0003-0866-0380)
- Lu Liu (ORCID: https://orcid.org/0000-0003-3289-8671)
- M. Wang (ORCID: https://orcid.org/0009-0004-0109-0068)
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1371/journal.pone.0330725
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wu Jieping Medical Foundation