Liver hypertrophy techniques: a position paper from the Italian Group of Regenerative and Occlusive Worldwide-used techniques of hepatic Hypertrophy (I GROWtoH)
In candidates for hepatectomy, different techniques to induce liver hypertrophy and modulate the future liver remnant are available. However, their use in specific clinical scenarios is highly heterogeneous and there is no consensus about minimal safety standards needed to incorporate these strategies into routine clinical practice. The aim of this position paper was to summarize newly available evidence in the field and compare medical practice among different hepatobiliary surgical units to evaluate the transformative potential of liver hypertrophy techniques in surgical oncology. This paper sets the stage for a future structured consensus on the application of liver hypertrophy techniques before hepatectomy.
Authors
- Gian Luca Grazi (ORCID: https://orcid.org/0000-0002-3279-0313)
- Cristina Mosconi (ORCID: https://orcid.org/0000-0001-6822-9053)
- Gianluca Rompianesi (ORCID: https://orcid.org/0000-0003-0756-8013)
- Luca Aldrighetti (ORCID: https://orcid.org/0000-0001-7729-2468)
- Nadia Russolillo (ORCID: https://orcid.org/0000-0002-0627-186X)
- Elio Jovine
- Mohammad Abu Hilal (ORCID: https://orcid.org/0000-0002-3162-4639)
- Ugo Boggi
- Giovanni Vennarecci (ORCID: https://orcid.org/0000-0001-9727-4304)
- Enrico Gringeri (ORCID: https://orcid.org/0000-0002-3459-7306)
- Luca Viganò (ORCID: https://orcid.org/0000-0002-4108-4832)
- Giorgio Ercolani (ORCID: https://orcid.org/0000-0003-4334-5167)
- Umberto Cillo (ORCID: https://orcid.org/0000-0002-2310-0245)
- Francesco De Cobelli (ORCID: https://orcid.org/0000-0003-4014-3711)
- Andrea Ruzzenente (ORCID: https://orcid.org/0000-0001-6911-563X)
- Alessandro Ferrero (ORCID: https://orcid.org/0000-0003-1504-5810)
- Marco Vivarelli (ORCID: https://orcid.org/0000-0001-8982-2163)
- Giammauro Berardi (ORCID: https://orcid.org/0000-0001-8827-9189)
- Matteo Cescon (ORCID: https://orcid.org/0000-0003-1715-3794)
- Alessandro Cucchetti (ORCID: https://orcid.org/0000-0001-5269-1964)
- Marco Massani (ORCID: https://orcid.org/0000-0001-6375-3577)
- Marcello Maestri (ORCID: https://orcid.org/0000-0002-5693-9151)
- Luciano De Carlis (ORCID: https://orcid.org/0000-0002-9133-8220)
- Damiano Patrono (ORCID: https://orcid.org/0000-0002-4096-4504)
- Paolo Magistri (ORCID: https://orcid.org/0000-0001-8326-069X)
- Salvatore Gruttadauria (ORCID: https://orcid.org/0000-0002-9684-8035)
- Riccardo Memeo (ORCID: https://orcid.org/0000-0002-1668-932X)
- Karl J. Oldhafer (ORCID: https://orcid.org/0000-0002-4878-265X)
- Vincenzo Mazzaferro (ORCID: https://orcid.org/0000-0002-4013-8085)
- Alberta Cappelli (ORCID: https://orcid.org/0000-0003-1142-3917)
- Matteo Serenari (ORCID: https://orcid.org/0000-0003-1471-8585)
- Carlo Sposito (ORCID: https://orcid.org/0000-0002-2276-2669)
- Francesco Ardito (ORCID: https://orcid.org/0000-0003-1596-2862)
- Matteo Ravaioli (ORCID: https://orcid.org/0000-0001-5862-6151)
- Felice Giuliante (ORCID: https://orcid.org/0000-0003-2087-2589)
- Pedro M. Baptista (ORCID: https://orcid.org/0000-0002-8969-7726)
- Erik Schadde (ORCID: https://orcid.org/0000-0003-4561-6469)
- Federico Mocchegiani (ORCID: https://orcid.org/0000-0003-0877-6535)
- Giuseppe Maria Ettorre
- Fabrizio Romano
- Fabrizio Di Benedetto (ORCID: https://orcid.org/0000-0002-6718-8760)
- Giacomo Zanus
- Francesco Izzo
- Roberto Troisi
- Massimo Fedi
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Verona (IT)
- University of Modena and Reggio Emilia (IT)
- Marche Polytechnic University (IT)
- Humanitas University (IT)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Southampton Hospital (US)
- Southampton General Hospital (GB)
- University of Catania (IT)
- Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo (ES)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Antonio Cardarelli (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Klinik Hirslanden (CH)
- Federico II University Hospital (IT)
- Azienda USL di Bologna (IT)
- Humanitas Gavazzeni (IT)
- Ospedale G.B. Morgagni - L.Pierantoni (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Hirslanden Klinik St. Anna (CH)
- Instituto de Investigación Sanitaria Aragón (ES)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Ospedale Generale Regionale Francesco Miulli (IT)
- Ca' Foncello Hospital (IT)
- Policlinico San Matteo Fondazione (IT)
- Carlo Forlanini Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Asklepios Klinik Barmbek (DE)
- Azienda Usl Toscana Centro (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- University of Southampton (GB)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Florence (IT)
- Rush University (US)
- Universidad Carlos III de Madrid (ES)
- University of Milano-Bicocca (IT)
- University of Palermo (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Updates in Surgery
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1007/s13304-025-02364-1
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Università di Bologna