Asymmetric Total Synthesis of Leptosphin C
A concise enantioselective total synthesis of leptosphine C (<b>1</b>) has been achieved. Our synthetic strategy features an unprecedented diastereo-/enantioselective Hajos-Parrish-Eder-Sauer-Wiechert (HPESW) reaction for construction of the AB ring system with continuous stereogenic centers (76% yield, 90% ee, dr = 19:1) and an uncommon Pauson-Khand (PK) reaction of geminal dimethyl alkenyl side chains for establishing the CD ring system with the quaternary carbon at C14.
Authors
- Lantian Sun
- Chenshan Lian
- Chi‐Sing Lee (ORCID: https://orcid.org/0000-0002-3564-8224)
- Zigang Li (ORCID: https://orcid.org/0000-0002-4649-1592)
- Xiaole Chen (ORCID: https://orcid.org/0009-0006-7355-1390)
- Jingyi Zhao (ORCID: https://orcid.org/0000-0002-3125-2716)
- Wei Han (ORCID: https://orcid.org/0000-0003-0759-1766)
Institutions
- Hong Kong Baptist University (HK)
- University Town of Shenzhen (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1021/acs.orglett.5c03236
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hong Kong Baptist University
- National Natural Science Foundation of China
- Research Grants Council, University Grants Committee
- Peking University
- Shenzhen Graduate School, Peking University