Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks

Two-thirds of individuals with prediabetes follow metabolically resilient trajectories, whereas distinct insulin-resistant or renal-dysfunction trajectories precede micro- or macrovascular complications, respectively. The optimal window for macrovascular complication prevention in individuals with prediabetes microalbuminuria may precede progression to T2D.

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Journal
Diabetes Care
Published
2025-08-26
DOI
https://doi.org/10.2337/dc25-0866
Citations
2
Primary Topic
Diabetes, Cardiovascular Risks, and Lipoproteins
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article
Field-Weighted Citation Impact
2.59

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article

Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks

Farida Rautaharju, Enrico Cagliero, Alafia Samuels, Ashley Guidi et al.
2 citations
Diabetes Care
Diabetes, Cardiovascular Risks, and Lipoproteins
2.59
article

Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks

Farida Rautaharju, Enrico Cagliero, Alafia Samuels, Ashley Guidi, Gina McAtee, Anna Bowers, Kathy Hattaway, Kenneth G. C. Smith, Kirsten Czech, Rosa Ruiz, Catherine Manus, Nancy J. Aronoff, Sharon M. Hall, John Reusing, Deborah Elsas, John C. Guare, Alan M. Jacobsen, Robin E. Yamamoto, Kali D’Anna, Susan Hagamen, Matthew J. O’Brien, Tara Dacawyma, Ysela Gonzales, Emily B. Schroeder, Sunder Mudaliar, William B. Applegate, Trevor J. Orchard, Wilfred Y. Fujimoto, Vanita R. Aroda, John Spandorfer, Maria Swift, Vickie L. Andre, Helen P. Hazuda, Mary A. Foulkes, Jennifer Arceneaux, Jonathan Scheindlin, Barbara Eberhardt, Vanessa Bradley, Dorothy Gohdes, Clara M. Smith, Asha K. Nair, Raed Imseis, Ellie Horse, Christopher Piromalli, Barbara Fargnoli, Alan R. Shuldiner, Narleen K. Baker-Ladao, Catherine Behrends, Diana Leos, Janet Sewenemewa, Holly Cohn, Darryl Tonemah, Sheila C. Steinke, Jane E. Lee, Sameh Tadros, Beverly Tseng, Jonalle M. Dowden, Nicole Butler, Leslie F. Atler, Janice Freel, Jeong W. Pak, Dace Trence, Catherine S. Poirier, Marsha Simmons, Danielle Powell, Mike Reidy, Ronald Goldberg, Carolyn M. Cantrell, Ann V. Schwartz, Bart Clark, Dana Schweizer, Cherie McCabe, Stacy Rubtchinsky, Gabriel I. Uwaifo, Christopher D. Saudek, Mary Beth Pena, Christine Darwin, Carmen Larreal, Lascelles Kirby, Kathleen M. Kobus, Catherine Benchoff, Maureen Passaro, Lisa Keasler, Henry Mosley, Jill P. Crandall, Rajesh Garg, Sandra T. Foo, José A. Luchsinger, Anna Giannella, Mary Beth Benson, Cheryl F. Smith, Tatiana Walker, Jeanine Roumain, Preethy Kolinjivadi, Steven Poirier, Mary Lou Carrion-Petersen, Edwin B. Fisher, Martia Glass, Yolanda F. Dotson, Roeland J.W. Middelbeek, Adrienne Allen, Doris A. Hernandez-McGinnis, Dawn Jiggetts, Kayla O’Neal, Kristina L. Grimes, Marjorie Bronsord, Lorna Dias, Emily Sullivan, Mimi M. Giles, Constance Pepe, François Aldrich, Chelsea Spencer, Rachel Williams, Fernelle Leandre, Leigh Perreault, Erin O’Kelly Phillips, Valerie Goldman, Marinella Temprosa, ARLETTE C. PERRY, Geraldine Boggs, David Keßler, Margaret Mills, Wendi Wildman, Evette Polczynski, Shandiin Begay, Carol Percy, Jason Kurland, Julia A. St. Amant, Richard F. Hamman, Jeanne Spellman, Cyndy Edgerton, Pamela G. Watson, Toni I. Pollin, Ruthanne Hilbrich, Thomas W. Shields, Cindy Evans, Om P. Ganda, Dione Lenz, Tsedenia Bezabeh, Sherita Hill Golden, Michelle Yazzie, Susan Roston, Sue Shapiro, Roberta Duncan, James H. Warram, Jonathan Krakoff, Angela Silverman, Marjorie K. Mau, Paul W. Franks, Julia Middendorf, Amber Dragg, Sandra Sangster, Elissa Violino, Lynne Delve, James M. Ignaut, Christine Stevens, Maureen A. Malloy, Robert Gooding, Joel Bethepu, Simona Szerdi Janesch, Frederick L. Brancati, Charlotte Dodge, Melanie Barkalow, Charlotte Stimpson, Amit R. Majithia, Natalie Andon, Ronald T. Ackermann, Valerie Ripley, Joel Zonszein, Larry B. Ballonoff, Pranav Sandilya Garimella, Mathew Guido, Solome Abebe, Tracy Whittington, Kathy Mikami, Robert Janicek, Laura H. Morris, Kevin Furlong, Janene L. Canady, Juan Isaac, Megan Lyman, Michael L. Jeffirs, Paula C. Vicknair, Jessica Pettigrew, Jennifer Truong, Cynthia Hurtenbach, Michelle Kerr, Gretchen Youssef, Ellen W. Seely, Maegan Harden, Judith Fradkin, Marcia A. Jackson, James O. Hill, Samuel S. Engel, Lisa Palermo, Jennifer Torio-Hurley, Lori Haffner, Allison Friedler, Elsie Adorno, Megan Fultz, Iris W. Culbert, Fonda G. Guillory, Pamela Vargo, Peter Lou, Jessica Harting, Samuel E. Dagogo-Jack, Angela L. Brown, Monica Salazar, Matthew Davis, Gregory W. Evans, Anne Goulding, Ellen S. Rooney, Kishore M. Gadde, Amy R. Sherman, Ernestine Brown, Michael Larsen, Nathaniel Linden-Santangeli, Marian Fitzgibbon, John M. Lachin, Patricia M. Rowe, Sandra L. Frieson, Jeanette Calles, Debra Wells-Thayer, Hannah Rapoport, Alexandra Poulos, Steven V. Edelman, Celeste C. Thomas, Deborah A. Sanford, Therese Franklin, Stephanie Guimond, Kerry J. Stewart, Sharon D. Jackson, Brent VanDorsten, Lee E. Melancon, Bonnie T. Jortberg, Brittnie Dotson, Angela Hadden, Katherine Horak, Yuping Gao, M. Kaye Kramer, Jean Park, Nisha Grover-Fairchild, Maryanne Nicosia, Marlene Frazier, Lyn M. Kula, Susan Cola, Hermes Flórez, A. V. Lowe, Monica Mullen, Valerie McLymont, Marion S. Kirkman, Norica Tomuta, Nancy Pemberton, Kristi Dohm, Martha Farago, Ellen J. Anderson, Mark R. Burge, Elizabeth A. Walker, Javiva Horne, Nnenna Agharanya, Carlos Lorenzo, Basma Fattaleh, Ted Ganiats, Elise Zimmerman, Kim Kelly-Dinham, Louise E. Ingraham, Linda Semler, Jacqueline M. Ghahate, Deloris Heard, F. Xavier Pi‐Sunyer, Khan Akbar, Sujata Jinagouda, Ebenezer A. Nyenwe, Padmini Rangamani, Renee Wiggins, Susie M. Kelly, Pamela A. Schinleber, Susan Harrier, Robert R. Henry, Stacey Kloiber, Patrice G. Saab, Lisa Chai, Mae K. Isonaga, David S. Schade, LeeLana Thomas, Maria Rosario G. Araneta, Karwyn S. Adams, Kathy Abbott, Beverly D. Porter, Elsayed Z. Soliman, Pharis Mohideen, José C. Florez, Bertha Veciana, George A. Bray, Robert J. Roy, Louann Harris, Marizel Quitingon, Kristy Bondi, Richard S. Katz, Elaine Grassa, Robert L. Hanson, Sarah Bassiouni, Arleen F. Brown, Andrea M. Kriska, Amitha Domalpally, Karen Kavena, William C. Knowler, Samia Das, Claudia Conzues, Dawn Myers, Linda M. Delahanty, Alla Sapozhnikova, Melvin Prince, Marycie Lamkin, Wylie McNabb, Amy D. Otto, Michelle Marr, Harelda Anderson, Alicia Noel, Nestoras Mathioudakis, Cheryl K.H. Johnson, Karen Vejvoda, Tina Brenneman, Kimberly Loman, Caitlin E. Carter, Erma Levy, Susan Reamer, Yabing Li, Ashley H. Tjaden, Alicia Greene, Steve Jones, Angela Goldstein, Tonya Jenkins, Crystal Duncan, Avnisha Patel, Michael Brändle, Naomi Katzir, Betty M. Kennedy, Kathleen Colleran, David D. McPherson, Preethi Srikanthan, Marie‐France Hivert, Valarie Weinzierl, Edwin S. Fineberg, Gregory M. Dwyer, Sumaya Castillo-Florez, Nancy Barrett, Madeline Beltran, Camille Natewa, Kathy Xapthalamous, April A. Herbert, Lauren N. Claravall, Medhat Botrous, Mary A. Hoskin, Kieren J. Mather, Karol E. Watson, Verónica Villarreal, Kati Swift, Willette Senter, Alvera Enote, Patricia Katz, William H. Herman, Renée W. Latimer, Riley Rainville, Kathy Parkes, Renee Liberoni, Marcella Chavez, Mary de Groot, Jocelyn Pan, Vonnie Gama, Lilia Leon, Maria Baldo, Jewel Mendoza, Sofya Rubinchik, Mark E. Molitch, Shelley R. Hoyer, Jackie Callaghan, Kristine A. Viscovich, Ronald A. Arky, Jillian Inouye, Helen Martinez, Karen M. Callaphan, Judith E. Soberman, Miriam Boraz, Marybeth Bryant, Hope Joseph, David B. Allison, Nadege Longchamp, Tamara B. Horwich, Ann R. Semenske, David G. Marrero, Christopher B. Toomey, Ateka Fondino, Perpetua Magpuri, Tracy Kellum, Ana Santiago, Susan Jeffries, Paula Putenney, Caroline Abbas, Denise Anderson, Laura Taylor, Jennifer Lukin, Kathy Ngo, Debra Rowse, Pamela Mucik, Mariana K. Johnson, Valerie Weinzierl, Kathleen E. Lawton, Kathy Chu, Steven E. Kahn, Anthony Sosa, Julie Bamdad, John S. Melish, Teresa Alexander, Annie Chatellier, Samantha Johnson, Evonne Utsey, Nolan Kuenster, Lonnese Taylor, Nina E. Bermudez, Bonny Rockette‐Wagner, Qing Pan, Jennifer J. Manly, Fredricka Walker-Murray, Thomas Nilan, Holly Love Burkott, Jeanne Charleston, Lisa Clifford, Helena Duffy, Daphne T. Adelman, Audrey McMaster, Jeanne M. Clark, Yolanda Nashboo, Cormarie Wernimont, Jennifer Dolgoff, Matthew S. Doughty, Harry Shamoon, Sarah Ledbury, Amisha Wallia, Lisa Testaverde, Andrew J. Sarkin, Nicholas Chan, Crystal J. Howard-Century, Lucy Ryder, Ruth Shaw, Peggy Gibbs, Gilda Trandafirescu, Paula Ruth Williamson, Heather Baumhauer, Robert Orlosky, Prajakta Khare-Ranade, Norman Cooeyate, Catherine Bavido-Arrage, Sharon K. Odom, Janet O. Brown, Shawne Stephens, Michelle Cook, Olga Lara, Kyle McDaniel, Marie Smith, Qurashia Manjoo, Lily M.K. Rutledge, Helen Lambeth, Celeste Colegrove, Jacqueline P. Burke, Hooman Oktaei, Monica Lockett, Caroline Navy, Sara Michaels, Chris Dailing, Ryan Endres, Santica Marcovina, Janet Tobian, Justin Glass, Carolyn Johannes, Karla A. Temple, Elyse Raymond, Ethel Faye Hampton, Sherron Cook, Arlene Martinez, Dorothy Pompi, Margaret J. Matulik, Samsam C. Penn, Paul Cassanova-Romero, Hanna Sherif, Ivy Morgan-Taggart, Zhuming Zhang, Jessica Sansoucy, Matthew Jay Budoff, Rena R. Wing, Susan I. Barr, Milvia Lagarda, Gretchen E.H. Van Wye, Erik J. Groessl, Frank L. Greenway, Penny Hyde, Emma Hurt, Peter H. Bennett, James Reimers, Edward W. Gregg, Robert E. Ratner, Cathryn F. Oldmixon, Evelyn C. Bird, Tara L. Jones, Charles McKitrick, Alexis Bouffard, Elizabeth J. Mayer‐Davis, Michelle Magee, Daniel Lawrence, Sheila Watson, Sharon L. Edelstein, Rebecca Culyba, Heather Turgeon, Monica Hartmuller, Claresa Levatan, Donald C. Simonson, Catherine DeSandre, Neil H. White, Marielle Mugford, Brian C. Bucca, Liane Cox, Tamara Stich, Priscilla Jay, Milajurine Lindsay, Raynette U. Perry, Emily Kobayashi, Beverly Williams-Cleaves, Juliet Sanguily, Debra Waters, Margaret Kocal, Catherine M. Champagne, Judith G. Regensteiner, William H. Polonsky, Roylen S. Kaskalla, Blandine Laferrère, Anthony A. Killeen, Nopporn Thangthaeng, Dana Dabelea, Lori Lambert, Judith Wylie‐Rosett, Michael Bryer‐Ash, Wendy Benz, Kellie A. Smith, Boyd E. Metzger, Ronald J. Prineas, Liana K. Billings, Uzoma N. Ibebuogu, Helen Chong, Donna H. Ryan, Elizabeth M. Venditti, Sharon Cappelli, Kelly J. Acton, Gaye Koenning, Miranda Smart, Kisha L. Pinner, Renee Reinhart, Medha N. Munshi, Ryan Gilligan, Ralph Beddow, Sunder Mudaliar, Elizabeth Stamm, Maria G. Montez, Andy Ewen, Maria Budget, Katherine V. Williams, Ellie Corkery, Claire Hemphill, B. Ned Calonge, Lindsery Gurry, Wayman W. Cheatham, Jerrold M. Olefsky, David Altshuler, Ping Zhang, Ling Chen, Christine Lee, David A. Ehrmann, Enrique Caballero, Costas A. Christophi, Ravi Goyal, Lisa L. Smith, Michelle Chan, Caren G. Solomon, Heather J. Hoffman, Morton B. Brown, Tara Wilson, Patrick J. Boyle, Patricia V. Nash, Rosalyn Barber, Lynne C. Lichtermann, David W. Price, Richard F. Arakaki, Edward S. Horton, Steven M. Haffner, Elizabeth Barrett‐Connor, Carissa M. Smith, April Thomas, James Rochon, Barry J. Goldstein, Robert H. Knopp, Jeff Curtis, Marsha Miller, Brenda K. Montgomery, Barbara Blodi, Greg Strylewicz, Kristin David, Nancy Rowland, Diane Larsen, Abbas E. Kitabchi, Tracy Jones, Charlton Wilson, R. Eastman, Sarah Fowler, Dan O’Leary, Richard P. Donahue, Fannie Smith, Charles J. Campbell, Julie A. Nelson, Jeffery J. Zachwieja, Amer Rassam, Carolyn King, Adrian Casillas, Laurie Bissett, Richard R. Rubin, Paris Roach, Kenneth S. Polonsky, Sanford Garfield, Kathleen Jablonski, Raymond P. Bain, Mary Larkin, Tonya Taylor, Jean Louise M. Smith, Madelyn L. Wheeler, Mary E. Murphy, Rhea Mundra, Ronald P. Danis, Larry D. Hubbard, Donald Williamson, Jennifer C. Lovejoy, Wendy Grant, John J. Albers, Julio V. Santiago, Mohammed F. Saad, Tina Morgan, Deloris Johnson, Pentti M. Rautaharju, Debra Clark, Harriet Ricks, Thomas Pitts, Deanna Gabrielson, Helen Seagle, Carmen Pal, Jadell Mendez, Susan Hensley, Debra Rubinstein, Lindsay Doherty, Edward W. Lipkin, Adrienne Gottlieb, Merry Jackson, Noemi Neira, Bonnie Gillis, Richard T. Tulley, Robert R. Moran, F. José, Anne Murillo, C Di Muro, David M. Nathan, Julie Hu, Brenda A. Broussard, Yong Ma, Emily Tsai
article en
2 citations

Abstract

Two-thirds of individuals with prediabetes follow metabolically resilient trajectories, whereas distinct insulin-resistant or renal-dysfunction trajectories precede micro- or macrovascular complications, respectively. The optimal window for macrovascular complication prevention in individuals with prediabetes microalbuminuria may precede progression to T2D.

Diabetes CareVol. 48(10)
University of California System (US), University of California San Diego (US), The Coordinating Center (US), VA San Diego Healthcare System (US)
Veterans Affairs San Diego Healthcare System, National Institute of Biomedical Imaging and Bioengineering, Division of Diabetes, Endocrinology, and Metabolic Diseases
Openalex Percentile: Top 9%
Diabetes, Cardiovascular Risks, and Lipoproteins
2.59
DOIOpen Access PDFOpenAlex
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