Multi-omics analysis of potential metabolic networks linking peripheral metabolic changes to inflammatory retinal conditions in STZ-induced early diabetic retinopathy
This study elucidates the upstream regulatory network of peripheral serum metabolites associated with early retinal lesions. Specifically, the SNPs in key peripheral enzyme genes may exert remote effects on retinal inflammation in DR. This finding provides insights into the systemic metabolic management and offering peripheral precise early detection and treatment.
Authors
- Mengxue Xia (ORCID: https://orcid.org/0000-0002-0181-3551)
- Manwen Yang
- Fang Zhang (ORCID: https://orcid.org/0000-0002-7000-554X)
- Yan Liu (ORCID: https://orcid.org/0000-0001-6868-5454)
- Xiaonan Zhang (ORCID: https://orcid.org/0000-0003-4359-9079)
- Yingjie Wu (ORCID: https://orcid.org/0000-0003-2675-2625)
Institutions
- Shanghai Jiao Tong University (CN)
- Dalian Medical University (CN)
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
- New York University (US)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102182
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71