Characterization of the tumor immune microenvironment in pregnancy-associated breast cancer through multiplex immunohistochemistry and transcriptome analyses
Using multiplex IHC and transcriptome analyses, this study demonstrated that PABC was associated with a higher abundance of immune cells, including increased infiltration of T cells, B cells, and macrophages, in the breast tumor microenvironment. Future research is required to focus on the role of immune cells in pregnancy-associated breast cancer patients.
Authors
- Yen‐Shen Lu (ORCID: https://orcid.org/0000-0001-7461-1291)
- Ching‐Hung Lin (ORCID: https://orcid.org/0000-0003-2403-4056)
- Tzu‐Pin Lu (ORCID: https://orcid.org/0000-0003-3697-0386)
- Chiun‐Sheng Huang (ORCID: https://orcid.org/0000-0002-6557-211X)
- Chia‐Lang Hsu (ORCID: https://orcid.org/0000-0002-7447-8045)
- Li‐Wei Tsai (ORCID: https://orcid.org/0000-0002-6877-0138)
- I-Chun Chen (ORCID: https://orcid.org/0000-0002-4645-0125)
- Ching‐Hsuan Chen (ORCID: https://orcid.org/0000-0002-1182-8191)
- Mingyang Wang (ORCID: https://orcid.org/0000-0001-7201-5090)
Institutions
- National Taiwan University (TW)
- Taipei City Hospital (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1186/s13058-025-02097-4
- Citations
- 4
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Ministry of Science and Technology, Taiwan
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council