DESIGN AND DEVELOPMENT OF BENZOTHIAZOLE- Β-LACTAM HYBRIDS FOR ANTIPROLIFERATIVE ACTIVITY: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUTION

In recent years, the discovery and development of new therapeutic agents has become a central focus of pharmaceutical research.The benzothiazole nucleus is recognized as a key structural motif in medicinal chemistry due to its diverse biological properties, including its role in enzyme inhibition, antimicrobial activity, and anti-inflammatory effects.Incorporating other functional groups or heterocyclic systems, such as lactam rings, into benzothiazole structures has been found to enhance their biological activity, making them promising candidates for further exploration [1].Lactam rings, known for their importance in various biological processes, are commonly used in drug design to improve the stability and bioavailability of active compounds.By combining the benzothiazole core with a lactam ring, researchers might create compounds with enhanced therapeutic properties, such as improved pharmacokinetics, target specificity, and reduced side effects [2].The synthesis of novel compounds with potential therapeutic applications is essential for addressing emerging health challenges.The development of benzothiazole derivatives clubbed with lactam rings offers a promising approach to discovering new molecules with improved biological efficacy.These compounds could be useful in a variety of fields, including the treatment of bacterial or viral infections, inflammatory disorders, and other ailments that require novel therapeutic interventions.This study intends to synthesize and characterize benzothiazole-lactam derivatives, evaluating their physicochemical properties and conducting silico studies to predict their biological interactions.By integrating computational methods with vitro testing, the research seeks to establish the relevance of these compounds for further development in therapeutic applications.