Analysis of the Innate Immune Response to Febrile UTI in Infants: Evidence of an Acute Cytokine Storm
Local and systemic hyperactivation of innate immunity characterizes acute pyelonephritis, a common and severe bacterial infection in childhood and a significant cause of urosepsis and mortality in adults. The results define a transient cytokine storm response, resembling that induced during severe acute respiratory syndrome coronavirus 2 infection, as characteristic of acute pyelonephritis, rather than individual protein biomarkers.
Authors
- Shahram Ahmadi (ORCID: https://orcid.org/0000-0001-5069-7131)
- Therese Rosenblad (ORCID: https://orcid.org/0000-0001-8088-0287)
- Per Brandström (ORCID: https://orcid.org/0000-0001-8269-4488)
- Inès Ambite (ORCID: https://orcid.org/0000-0003-1470-671X)
- Catharina Svanborg (ORCID: https://orcid.org/0000-0001-8145-0553)
- Samudra Sabari
- Magnus Lindén (ORCID: https://orcid.org/0000-0002-0429-2624)
- Sing Ming Chao
Institutions
- Lund University (SE)
- Drottning Silvias barn- och ungdomssjukhus (SE)
- KK Women's and Children's Hospital (SG)
- Hallands sjukhus Halmstad (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1097/inf.0000000000004914
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00