Use of Pre and Post Comparison of Intra-lesional Infiltration of Dexamethasone Plus Hyaluronidase in Management of Patients with OSMF

Background: Oral Submucous Fibrosis (OSMF) is a potentially malignant condition of the oral mucosa, characterized by fibrosis and epithelial atrophy. Treatment options have varied, with intra-lesional steroid injections being commonly used. This study evaluates the efficacy of dexamethasone combined with hyaluronidase in managing OSMF. Objective: To evaluate the pre- and post-treatment effects of intra-lesional dexamethasone combined with hyaluronidase on patients with OSMF. Methods: A prospective clinical study was conducted on 30 OSMF patients. Intra-lesional injections of dexamethasone (4 mg/mL) and hyaluronidase (150 IU/mL) were administered at weekly intervals for a total of 6 weeks. Clinical parameters such as mouth opening, pain, burning sensation, and oral mucosal changes were assessed pre- and post-treatment. Results: Significant improvement was observed in mouth opening, pain, and burning sensation, with histopathological improvement in fibrosis. Conclusion: Intra-lesional dexamethasone plus hyaluronidase is an effective treatment modality for managing OSMF, showing clinical and histopathological improvement. Keywords: OSMF, Dexamethasone, Hyaluronidase, Intra-lesional Injection, Mouth Opening, Fibrosis, Treatment, Management.