Melanocortin System Activates Carotid Body Arterial Chemoreceptors in Hypertension
Collectively, our data indicate a primarily pathophysiological role of melanocortin signaling in arterial chemosensation, contributing to excess sympathetic activity in cardiometabolic disease.
Authors
- Dainius H. Pauža (ORCID: https://orcid.org/0000-0001-8597-4370)
- Kazuhiro Nakamura (ORCID: https://orcid.org/0000-0002-6095-8996)
- Johannes Broichhagen (ORCID: https://orcid.org/0000-0003-3084-6595)
- David Murphy (ORCID: https://orcid.org/0000-0003-2946-0353)
- Pratik Thakkar (ORCID: https://orcid.org/0000-0003-2366-3862)
- David J. Hodson (ORCID: https://orcid.org/0000-0002-8641-8568)
- Xin Shen (ORCID: https://orcid.org/0000-0003-4429-8358)
- Fiona D. McBryde (ORCID: https://orcid.org/0000-0002-5687-9101)
- Manami Oya (ORCID: https://orcid.org/0009-0003-0238-9603)
- Kilian Roßmann (ORCID: https://orcid.org/0000-0003-4965-9669)
- Audrys G. Pauža (ORCID: https://orcid.org/0000-0001-9635-8872)
- Igor Felippe (ORCID: https://orcid.org/0000-0002-8582-2104)
- Julian F.R. Paton (ORCID: https://orcid.org/0000-0002-7527-5493)
Institutions
- Lithuanian University of Health Sciences (LT)
- University of Auckland (NZ)
- University of Bristol (GB)
- The Centre for Health (New Zealand) (NZ)
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (DE)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- Nagoya University (JP)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1161/circresaha.125.326394
- Citations
- 2
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 1.83