Lkb1 Downregulation Links PVAT Remodeling to Aortic Dilation or Aneurysm
Our work strongly suggests that Lkb1 deficiency in PVAT drives vascular smooth muscle cell phenotypic switching and aortic dilation and aneurysm formation. Lkb1, via its regulation of renin-angiotensin system in PVAT, maintains vessel homeostasis.
Authors
- Min Liang (ORCID: https://orcid.org/0000-0002-3201-9131)
- Zhaohua Cai (ORCID: https://orcid.org/0000-0001-8642-9040)
- Yunwen Hu
- Haiping Chen
- Yangjing Jiang (ORCID: https://orcid.org/0000-0002-7362-7125)
- Linghong Shen (ORCID: https://orcid.org/0000-0002-4387-4109)
- Huanhuan Huo (ORCID: https://orcid.org/0000-0002-3040-2882)
- Ben He (ORCID: https://orcid.org/0000-0001-5829-5903)
- Yijie Huang (ORCID: https://orcid.org/0000-0002-3742-4208)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-08-26
- DOI
- https://doi.org/10.1161/circresaha.125.326297
- Citations
- 3
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81